TY - JOUR
T1 - HEPATIC OSTEODYSTROPHY IN PRIMARY BILIARY CIRRHOSIS
T2 - A POSSIBLE DEFECT IN KUPFFER CELL MEDIATED CLEAVAGE OF PARATHYROID HORMONE
AU - ATKINSON, M. J.
AU - VIDO, I.
AU - KECK, E.
AU - HESCH, R. ‐D
PY - 1983/7
Y1 - 1983/7
N2 - Twelve of fourteen female patients with primary biliary cirrhosis, receiving vitamin D supplementation, exhibited unequivocal signs of osteoporosis but not of osteomalacia. Vitamin D treatment reproduced normal 25‐hydroxyvitamin D levels in all but two patients and the 1,25 and 24,25‐dihydroxyvitamin D metabolic pathways appeared to be unimpaired. A possible mechanism for the vitamin D resistant osteoporosis has been identified following the observation that, in those patients with severe cirrhosis, the circulating concentration of intact PTH was elevated. The increase in intact hormone appears to be at the expense of the carboxyl‐regional PTH produced by hepatic Kupffer cell mediated cleavage of intact PTH. As a defect in Kupffer cell function is documented in primary biliary cirrhosis we postulate that the increased intact PTH/decreased carboxyl‐regional PTH concentrations arise as a result of diminished Kupffer cell mediated cleavage. The reduced generation of cleaved PTH, due to this loss of Kupffer cell activity, would thus contribute to the development of osteoporosis in primary biliary cirrhosis.
AB - Twelve of fourteen female patients with primary biliary cirrhosis, receiving vitamin D supplementation, exhibited unequivocal signs of osteoporosis but not of osteomalacia. Vitamin D treatment reproduced normal 25‐hydroxyvitamin D levels in all but two patients and the 1,25 and 24,25‐dihydroxyvitamin D metabolic pathways appeared to be unimpaired. A possible mechanism for the vitamin D resistant osteoporosis has been identified following the observation that, in those patients with severe cirrhosis, the circulating concentration of intact PTH was elevated. The increase in intact hormone appears to be at the expense of the carboxyl‐regional PTH produced by hepatic Kupffer cell mediated cleavage of intact PTH. As a defect in Kupffer cell function is documented in primary biliary cirrhosis we postulate that the increased intact PTH/decreased carboxyl‐regional PTH concentrations arise as a result of diminished Kupffer cell mediated cleavage. The reduced generation of cleaved PTH, due to this loss of Kupffer cell activity, would thus contribute to the development of osteoporosis in primary biliary cirrhosis.
UR - http://www.scopus.com/inward/record.url?scp=0020540586&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.1983.tb00738.x
DO - 10.1111/j.1365-2265.1983.tb00738.x
M3 - Article
C2 - 6311459
AN - SCOPUS:0020540586
SN - 0300-0664
VL - 19
SP - 21
EP - 28
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 1
ER -