Hedgehog signalling in cancer formation and maintenance

Marina Pasca Di Magliano; Matthias Hebrok

doi:10.1038/nrc1229

Hedgehog signalling in cancer formation and maintenance

Marina Pasca Di Magliano
, Matthias Hebrok

University of California San Francisco

Research output: Contribution to journal › Review article › peer-review

767 Scopus citations

Abstract

The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.

Original language	English
Pages (from-to)	903-911
Number of pages	9
Journal	Nature Reviews Cancer
Volume	3
Issue number	12
DOIs	https://doi.org/10.1038/nrc1229
State	Published - Dec 2003
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1038/nrc1229

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title = "Hedgehog signalling in cancer formation and maintenance",

abstract = "The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.",

author = "\{Di Magliano\}, \{Marina Pasca\} and Matthias Hebrok",

note = "Funding Information: We would like to dedicate this manuscript to the memory of Ira Herskowitz, who inspired us to contemplate about the connection between embryonic signalling pathways and cancer. We would like to thank all members of the Hebrok laboratory for stimulating discussions. In particular, we would like to thank P. Heiser and J. Lau as well as H. Kawahira, D. Cano and M. Tzanakakis for critical reading of the manuscript. Work in M. H.{\textquoteright}s laboratory was supported by grants from the Juvenile Diabetes Research Foundation, the Hillblom Foundation and the National Institutes of Health.",

year = "2003",

month = dec,

doi = "10.1038/nrc1229",

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journal = "Nature Reviews Cancer",

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AU - Di Magliano, Marina Pasca

AU - Hebrok, Matthias

N1 - Funding Information: We would like to dedicate this manuscript to the memory of Ira Herskowitz, who inspired us to contemplate about the connection between embryonic signalling pathways and cancer. We would like to thank all members of the Hebrok laboratory for stimulating discussions. In particular, we would like to thank P. Heiser and J. Lau as well as H. Kawahira, D. Cano and M. Tzanakakis for critical reading of the manuscript. Work in M. H.’s laboratory was supported by grants from the Juvenile Diabetes Research Foundation, the Hillblom Foundation and the National Institutes of Health.

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N2 - The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.

AB - The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.

UR - https://www.scopus.com/pages/publications/0345059765

U2 - 10.1038/nrc1229

DO - 10.1038/nrc1229

M3 - Review article

C2 - 14737121

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SN - 1474-175X

VL - 3

SP - 903

EP - 911

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 12

ER -

Hedgehog signalling in cancer formation and maintenance

Abstract

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