TY - JOUR
T1 - Hedgehog signalling in cancer formation and maintenance
AU - Di Magliano, Marina Pasca
AU - Hebrok, Matthias
N1 - Funding Information:
We would like to dedicate this manuscript to the memory of Ira Herskowitz, who inspired us to contemplate about the connection between embryonic signalling pathways and cancer. We would like to thank all members of the Hebrok laboratory for stimulating discussions. In particular, we would like to thank P. Heiser and J. Lau as well as H. Kawahira, D. Cano and M. Tzanakakis for critical reading of the manuscript. Work in M. H.’s laboratory was supported by grants from the Juvenile Diabetes Research Foundation, the Hillblom Foundation and the National Institutes of Health.
PY - 2003/12
Y1 - 2003/12
N2 - The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.
AB - The Hedgehog signalling pathway is essential for numerous processes during embryonic development. Members of this family of secreted proteins control cell proliferation, differentiation and tissue patterning in a dose-dependent manner. Although the overall activity of the pathway is diminished after embryogenesis, recent reports show that the pathway remains active in some adult tissues, including adult stem cells in the brain and skin. There is also evidence that uncontrolled activation of the pathway results in specific types of cancer.
UR - http://www.scopus.com/inward/record.url?scp=0345059765&partnerID=8YFLogxK
U2 - 10.1038/nrc1229
DO - 10.1038/nrc1229
M3 - Review article
C2 - 14737121
AN - SCOPUS:0345059765
SN - 1474-175X
VL - 3
SP - 903
EP - 911
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 12
ER -
