Hamatologische Veranderungen bei alimentarem Pb-Mangel wachsender Ratten

The effect of an alimentary Pb-deficiency on hematological parameters was examined in two growth- and one generation-experiments with female Sprague Dawley rats. The animals were fed a semisynthetic casein-based diet supplemented with 0 ppb up to 800 ppb Pb as Pb-II-acetate-3-hydrate. In two experiments the blood parameters of the rats of G₀-generation fed the diet poor in Pb were changed to a normocytic, normochrome pancytopenia at day 21 resp. 28 of the experiments. At day 28 resp. 41 the blood parameters normalized resp. the different Pb-supply in the diet only effected the mean corpuscular volume- and mean corpuscular hemoglobin-values. It was assumed that the disturbances in blood parameters at deficient Pb-supply are caused by temporary hemolysis.