Hamatologische Veranderungen bei alimentarem Pb-Mangel wachsender Ratten

Translated title of the contribution: Hematological changes resulting from alimentary Pb-deficiency in growing rats

J. Eberle, A. M. Reichlmayr-Lais, M. Kirchgessner

Research output: Contribution to journalArticlepeer-review


The effect of an alimentary Pb-deficiency on hematological parameters was examined in two growth- and one generation-experiments with female Sprague Dawley rats. The animals were fed a semisynthetic casein-based diet supplemented with 0 ppb up to 800 ppb Pb as Pb-II-acetate-3-hydrate. In two experiments the blood parameters of the rats of G0-generation fed the diet poor in Pb were changed to a normocytic, normochrome pancytopenia at day 21 resp. 28 of the experiments. At day 28 resp. 41 the blood parameters normalized resp. the different Pb-supply in the diet only effected the mean corpuscular volume- and mean corpuscular hemoglobin-values. It was assumed that the disturbances in blood parameters at deficient Pb-supply are caused by temporary hemolysis.

Translated title of the contributionHematological changes resulting from alimentary Pb-deficiency in growing rats
Original languageGerman
Pages (from-to)292-301
Number of pages10
JournalZeitschrift fur Ernahrungswissenschaft
Issue number3
StatePublished - 1996


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