Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma

Marie Mikuteit; Stefanie Zschäbitz; Maximilian Erlmeier; Michael Autenrieth; Wilko Weichert; Arndt Hartmann; Sandra Steffens; Franziska Erlmeier

doi:10.1159/000525601

Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma

Marie Mikuteit, Stefanie Zschäbitz, Maximilian Erlmeier, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Sandra Steffens, Franziska Erlmeier

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. Aim: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). Material and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6- compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. Conclusion: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

Original language	English
Pages (from-to)	536-541
Number of pages	6
Journal	Oncology
Volume	100
Issue number	10
DOIs	https://doi.org/10.1159/000525601
State	Published - 1 Oct 2022
Externally published	Yes

Keywords

Chromophobe histology
Growth arrest-specific protein 6
Renal cell carcinoma
Survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000525601

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@article{847c60c92fa74e8fa5bbf3bccf9ec687,

title = "Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma",

abstract = "Background: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. Aim: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). Material and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6- compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. Conclusion: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.",

keywords = "Chromophobe histology, Growth arrest-specific protein 6, Renal cell carcinoma, Survival",

author = "Marie Mikuteit and Stefanie Zsch{\"a}bitz and Maximilian Erlmeier and Michael Autenrieth and Wilko Weichert and Arndt Hartmann and Sandra Steffens and Franziska Erlmeier",

year = "2022",

month = oct,

day = "1",

doi = "10.1159/000525601",

language = "English",

volume = "100",

pages = "536--541",

journal = "Oncology",

issn = "0030-2414",

publisher = "S. Karger AG",

number = "10",

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TY - JOUR

T1 - Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma

AU - Mikuteit, Marie

AU - Zschäbitz, Stefanie

AU - Erlmeier, Maximilian

AU - Autenrieth, Michael

AU - Weichert, Wilko

AU - Hartmann, Arndt

AU - Steffens, Sandra

AU - Erlmeier, Franziska

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Background: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. Aim: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). Material and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6- compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. Conclusion: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

AB - Background: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. Aim: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). Material and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6- compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. Conclusion: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

KW - Chromophobe histology

KW - Growth arrest-specific protein 6

KW - Renal cell carcinoma

KW - Survival

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U2 - 10.1159/000525601

DO - 10.1159/000525601

M3 - Article

C2 - 35760058

AN - SCOPUS:85138672037

SN - 0030-2414

VL - 100

SP - 536

EP - 541

JO - Oncology

JF - Oncology

IS - 10

ER -

Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma

Abstract

Keywords

UN SDGs

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