Grenzgänger: Adult bone marrow cells populate the brain

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14 Scopus citations


While the brain has traditionally been considered a rather secluded site, recent studies suggest that adult bone marrow (BM)-derived stem cells can generate glia and neurons in rodents and humans. Macrophages and microglia are the first to appear in the murine brain after transplantation of genetically marked BM cells. Within weeks after transplantation, some authors have found astrocytes and cells expressing neuronal antigens. We detected cerebellar Purkinje neurons and interneutons, such as basket cells, expressing the green fluorescent protein (GFP) 10-15 months after transplantation of GFP-labeled BM cells. The results push the boundaries of our classic view of lineage restriction.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalHistochemistry and Cell Biology
Issue number2
StatePublished - 1 Aug 2003
Externally publishedYes


  • Bone marrow transplantation
  • Central nervous system
  • Glia
  • Green fluorescent protein
  • Neurons
  • Stem cells


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