Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma

Miriam Pipeleers-Marichal, Anita Goossens, Boudewijn De Waele, Günter Klöppel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number2
StatePublished - Jun 1990
Externally publishedYes


  • Appendiceal neuroma
  • Appendix
  • Granular cell tumour
  • Radiation injury


Dive into the research topics of 'Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma'. Together they form a unique fingerprint.

Cite this