Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma

Miriam Pipeleers-Marichal; Anita Goossens; Boudewijn De Waele; Günter Klöppel

doi:10.1007/BF02190537

Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma

Miriam Pipeleers-Marichal, Anita Goossens, Boudewijn De Waele, Günter Klöppel

Universitair Ziekenhuis Brussel

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	Virchows Archiv A Pathological Anatomy and Histopathology
Volume	417
Issue number	2
DOIs	https://doi.org/10.1007/BF02190537
State	Published - Jun 1990
Externally published	Yes

Keywords

Appendiceal neuroma
Appendix
Granular cell tumour
Radiation injury

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10.1007/BF02190537

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title = "Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma",

abstract = "We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.",

keywords = "Appendiceal neuroma, Appendix, Granular cell tumour, Radiation injury",

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AU - Pipeleers-Marichal, Miriam

AU - Goossens, Anita

AU - De Waele, Boudewijn

AU - Klöppel, Günter

PY - 1990/6

Y1 - 1990/6

N2 - We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.

AB - We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.

KW - Appendiceal neuroma

KW - Appendix

KW - Granular cell tumour

KW - Radiation injury

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SN - 0174-7398

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JO - Virchows Archiv A Pathological Anatomy and Histopathology

JF - Virchows Archiv A Pathological Anatomy and Histopathology

IS - 2

ER -

Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma

Abstract

Keywords

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