Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro

M. Serratice; B. Bertrand; E. F.J. Janssen; E. Hemelt; A. Zucca; F. Cocco; M. A. Cinellu; A. Casini

doi:10.1039/c4md00241e

Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro

M. Serratice, B. Bertrand, E. F.J. Janssen, E. Hemelt, A. Zucca, F. Cocco, M. A. Cinellu, A. Casini

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A number of gold(i) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H ⁺-ATPase-mediated mechanism.

Original language	English
Pages (from-to)	1418-1422
Number of pages	5
Journal	MedChemComm
Volume	5
Issue number	9
DOIs	https://doi.org/10.1039/c4md00241e
State	Published - Sep 2014
Externally published	Yes

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10.1039/c4md00241e

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title = "Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro",

abstract = "A number of gold(i) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H +-ATPase-mediated mechanism.",

author = "M. Serratice and B. Bertrand and Janssen, {E. F.J.} and E. Hemelt and A. Zucca and F. Cocco and Cinellu, {M. A.} and A. Casini",

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T1 - Gold(i) compounds with lansoprazole-type ligands

T2 - Synthesis, characterization and anticancer properties in vitro

AU - Serratice, M.

AU - Bertrand, B.

AU - Janssen, E. F.J.

AU - Hemelt, E.

AU - Zucca, A.

AU - Cocco, F.

AU - Cinellu, M. A.

AU - Casini, A.

PY - 2014/9

Y1 - 2014/9

N2 - A number of gold(i) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H +-ATPase-mediated mechanism.

AB - A number of gold(i) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy) pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H +-ATPase-mediated mechanism.

UR - http://www.scopus.com/inward/record.url?scp=84906557511&partnerID=8YFLogxK

U2 - 10.1039/c4md00241e

DO - 10.1039/c4md00241e

M3 - Article

AN - SCOPUS:84906557511

SN - 2040-2503

VL - 5

SP - 1418

EP - 1422

JO - MedChemComm

JF - MedChemComm

IS - 9

ER -

Gold(i) compounds with lansoprazole-type ligands: Synthesis, characterization and anticancer properties in vitro

Abstract

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