Gold-catalyzed benzylation of arenes and heteroarenes

Kristin Mertins, Irina Iovel, Jette Kischel, Alexander Zapf, Matthias Beller

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Friedel-Crafts type benzylation of arenes and heteroarenes with benzylic acetates, alcohols, and carbonates is effectively promoted under mild reaction conditions using catalytic amounts of gold salts. The resulting 1,1-diarylalkanes and 1-aryl-1-heteroarylalkanes are obtained in high yields and with high selectivity. The utility of the method is demonstrated by a short synthesis of beclobrate {ethyl 2-[4-(4-chlorobenzyl)-phenoxy]-2-methylbutyrate (3)}, a fibric acid derivative.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalAdvanced Synthesis and Catalysis
Volume348
Issue number6
DOIs
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Arene functionalization
  • Arylation
  • Benzylation
  • Friedel-Crafts reaction
  • Gold
  • Homogeneous catalysis

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