GnRH receptor signalling to ERK: kinetics and compartmentalization

Christopher James Caunt, Ann R. Finch, Kathleen R. Sedgley, Craig A. McArdle

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

Many hormones, neurotransmitters and growth factors influence their target cells by activation of mitogen-activated protein kinase cascades. The consequences of such activation reflect not only the magnitude, but also the kinetics and cellular compartmentalization of kinase activity. Gonadotropin-releasing hormone (GnRH) receptors are seven-transmembrane receptors that have undergone a period of rapidly accelerated molecular evolution in which the advent of type I mammalian GnRH receptors has been associated with the loss of the carboxyl-terminal tail, a structure present in all other seven-transmembrane receptors. Here, we review spatiotemporal aspects of extracellular-signal-regulated kinase activation by gonadotropin-releasing hormone receptors, emphasizing how the absence or presence of the carboxyl-terminal tail dictates the receptors' ability to engage and signal via arrestins.

Original languageEnglish
Pages (from-to)308-313
Number of pages6
JournalTrends in Endocrinology and Metabolism
Volume17
Issue number8
DOIs
StatePublished - Oct 2006
Externally publishedYes

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