GnRH Action: GnRH Signaling

Kathryn L. Garner; Krasimira Tsaneva-Atanasova; Craig A. McArdle

doi:10.1007/978-3-319-44441-3_2

GnRH Action: GnRH Signaling

Kathryn L. Garner, Krasimira Tsaneva-Atanasova, Craig A. McArdle

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Gonadotropin-releasing hormone (GnRH) mediates central control of reproductive function by activation of G-protein-coupled receptors on pituitary gonadotropes. These G_q-coupled receptors mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone and follicle-stimulating hormone and also chronic regulation of the synthesis of these gonadotropin hormones. GnRH is secreted in brief pulses and GnRH effects on its target cells are dependent upon the characteristics of these pulses. Here we provide an overview of GnRH receptors and their signaling network, emphasizing novel and atypical functional features of GnRH signaling, and mechanisms mediating pulsatile hormone signaling.

Original language	English
Title of host publication	Endocrinology (Switzerland)
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	35-70
Number of pages	36
DOIs	https://doi.org/10.1007/978-3-319-44441-3_2
State	Published - 2017
Externally published	Yes

Publication series

Name	Endocrinology (Switzerland)
ISSN (Print)	2510-1927
ISSN (Electronic)	2510-1935

Keywords

ERK
G-proteins
GnRH
GnRH receptors
MAPK
NFAT
Phospholipase C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-319-44441-3_2

Cite this

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title = "GnRH Action: GnRH Signaling",

abstract = "Gonadotropin-releasing hormone (GnRH) mediates central control of reproductive function by activation of G-protein-coupled receptors on pituitary gonadotropes. These Gq-coupled receptors mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone and follicle-stimulating hormone and also chronic regulation of the synthesis of these gonadotropin hormones. GnRH is secreted in brief pulses and GnRH effects on its target cells are dependent upon the characteristics of these pulses. Here we provide an overview of GnRH receptors and their signaling network, emphasizing novel and atypical functional features of GnRH signaling, and mechanisms mediating pulsatile hormone signaling.",

keywords = "ERK, G-proteins, GnRH, GnRH receptors, MAPK, NFAT, Phospholipase C",

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doi = "10.1007/978-3-319-44441-3_2",

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AU - Tsaneva-Atanasova, Krasimira

AU - McArdle, Craig A.

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Y1 - 2017

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AB - Gonadotropin-releasing hormone (GnRH) mediates central control of reproductive function by activation of G-protein-coupled receptors on pituitary gonadotropes. These Gq-coupled receptors mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone and follicle-stimulating hormone and also chronic regulation of the synthesis of these gonadotropin hormones. GnRH is secreted in brief pulses and GnRH effects on its target cells are dependent upon the characteristics of these pulses. Here we provide an overview of GnRH receptors and their signaling network, emphasizing novel and atypical functional features of GnRH signaling, and mechanisms mediating pulsatile hormone signaling.

KW - ERK

KW - G-proteins

KW - GnRH

KW - GnRH receptors

KW - MAPK

KW - NFAT

KW - Phospholipase C

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M3 - Chapter

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BT - Endocrinology (Switzerland)

PB - Springer Science and Business Media Deutschland GmbH

ER -

GnRH Action: GnRH Signaling

Abstract

Publication series

Keywords

UN SDGs

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