Glutamate-induced cell death in neuronal HT22 cells is attenuated by extracts from St. John's wort (Hypericum perforatum L.)

Anja Breyer, Matthias Elstner, Thomas Gillessen, Dieter Weiser, Erich Elstner

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Glutamate-induced cell death of hippocampal HT22 cells is a model system for neuronal disorders due to depletion of glutathione levels and increase of intracellular reactive oxygen species. Standardized extracts of Hypericum perforatum (HPE) contain flavonoids known for antioxidative properties. In the above model, cytoprotective effects at a concentration of 0.05% HPE by attenuation of calcium fluxes and cellular energy statuses are reported.

Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalPhytomedicine
Volume14
Issue number4
DOIs
StatePublished - 10 Apr 2007

Keywords

  • Antioxidants
  • Cytoprotective effects
  • Glutamate-induced cell death in neuronal HT22 cells
  • Hypericum flavonoids
  • Reactive oxygen

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