Ghrelin

T. D. Müller; R. Nogueiras; M. L. Andermann; Z. B. Andrews; S. D. Anker; J. Argente; R. L. Batterham; S. C. Benoit; C. Y. Bowers; F. Broglio; F. F. Casanueva; D. D'Alessio; I. Depoortere; A. Geliebter; E. Ghigo; P. A. Cole; M. Cowley; D. E. Cummings; A. Dagher; S. Diano; S. L. Dickson; C. Diéguez; R. Granata; H. J. Grill; K. Grove; K. M. Habegger; K. Heppner; M. L. Heiman; L. Holsen; B. Holst; A. Inui; J. O. Jansson; H. Kirchner; M. Korbonits; B. Laferrère; C. W. LeRoux; M. Lopez; S. Morin; M. Nakazato; R. Nass; D. Perez-Tilve; P. T. Pfluger; T. W. Schwartz; R. J. Seeley; M. Sleeman; Y. Sun; L. Sussel; J. Tong; M. O. Thorner; A. J. van der Lely; L. H.T. van der Ploeg; J. M. Zigman; M. Kojima; K. Kangawa; R. G. Smith; T. Horvath; M. H. Tschöp

doi:10.1016/j.molmet.2015.03.005

Ghrelin

T. D. Müller
, R. Nogueiras
, M. L. Andermann
, Z. B. Andrews
, S. D. Anker
, J. Argente
, R. L. Batterham
, S. C. Benoit
, C. Y. Bowers
, F. Broglio
, F. F. Casanueva
, D. D'Alessio
, I. Depoortere
, A. Geliebter
, E. Ghigo
, P. A. Cole
, M. Cowley
, D. E. Cummings
, A. Dagher
, S. Diano

S. L. Dickson, C. Diéguez, R. Granata, H. J. Grill, K. Grove, K. M. Habegger, K. Heppner, M. L. Heiman, L. Holsen, B. Holst, A. Inui, J. O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C. W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P. T. Pfluger, T. W. Schwartz, R. J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M. O. Thorner, A. J. van der Lely, L. H.T. van der Ploeg, J. M. Zigman, M. Kojima, K. Kangawa, R. G. Smith, T. Horvath, M. H. Tschöp

Medicine and Health

Helmholtz Zentrum München German Research Center for Environmental Health
University of Santiago de Compostela
Harvard Medical School
Monash University
Charité – Universitätsmedizin Berlin
Hospital Universitario de la Princesa
Instituto de Salud Carlos III
University College London
University of Cincinnati College of Medicine
Tulane University Health Sciences Center
University of Torino
Hospital Clínico Universitario de Santiago de Compostela
Duke University School of Medicine
KU Leuven
Vagelos College of Physicians and Surgeons
Johns Hopkins School of Medicine
University of Washington School of Medicine
McGill University
Yale University Medical School
Göteborgs Universitet
University of Santiago de Compostela-Instituto de Investigación Sanitaria
University of Pennsylvania School of Arts and Sciences
Oregon National Primate Research Center
University of Alabama at Birmingham School of Medicine
NuMe Health
Brigham and Women's Hospital
University of Copenhagen
Kagoshima University Graduate School of Medical and Dental Sciences
Universitätsklinikum Schleswig-Holstein Campus Lübeck
Barts and The London School of Medicine and Dentistry
University College Dublin
University of Miyazaki Faculty of Medicine
University of Virginia
D.
University of Michigan Medical School
Baylor College of Medicine
Columbia University
Erasmus University Medical Center
Rhythm Pharmaceuticals, Inc.
University of Texas Southwestern Medical Center
Kurume University
National Cerebral and Cardiovascular Center
Department of Neuroscience

Research output: Contribution to journal › Review article › peer-review

982 Scopus citations

Abstract

The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original language	English
Pages (from-to)	437-460
Number of pages	24
Journal	Molecular Metabolism
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/j.molmet.2015.03.005
State	Published - 1 Jun 2015

Keywords

Ghrelin
Growth hormone segretagogue receptor

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10.1016/j.molmet.2015.03.005

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Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., ... Tschöp, M. H. (2015). Ghrelin. Molecular Metabolism, 4(6), 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

@article{7c47c98742bb44fabcf0fe713b281ac7,

title = "Ghrelin",

abstract = "The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",

keywords = "Ghrelin, Growth hormone segretagogue receptor",

author = "M{\"u}ller, \{T. D.\} and R. Nogueiras and Andermann, \{M. L.\} and Andrews, \{Z. B.\} and Anker, \{S. D.\} and J. Argente and Batterham, \{R. L.\} and Benoit, \{S. C.\} and Bowers, \{C. Y.\} and F. Broglio and Casanueva, \{F. F.\} and D. D'Alessio and I. Depoortere and A. Geliebter and E. Ghigo and Cole, \{P. A.\} and M. Cowley and Cummings, \{D. E.\} and A. Dagher and S. Diano and Dickson, \{S. L.\} and C. Di{\'e}guez and R. Granata and Grill, \{H. J.\} and K. Grove and Habegger, \{K. M.\} and K. Heppner and Heiman, \{M. L.\} and L. Holsen and B. Holst and A. Inui and Jansson, \{J. O.\} and H. Kirchner and M. Korbonits and B. Laferr{\`e}re and LeRoux, \{C. W.\} and M. Lopez and S. Morin and M. Nakazato and R. Nass and D. Perez-Tilve and Pfluger, \{P. T.\} and Schwartz, \{T. W.\} and Seeley, \{R. J.\} and M. Sleeman and Y. Sun and L. Sussel and J. Tong and Thorner, \{M. O.\} and \{van der Lely\}, \{A. J.\} and \{van der Ploeg\}, \{L. H.T.\} and Zigman, \{J. M.\} and M. Kojima and K. Kangawa and Smith, \{R. G.\} and T. Horvath and Tsch{\"o}p, \{M. H.\}",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.molmet.2015.03.005",

language = "English",

volume = "4",

pages = "437--460",

journal = "Molecular Metabolism",

issn = "2212-8778",

publisher = "Elsevier GmbH",

number = "6",

}

Müller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Diéguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO, van der Lely, AJ, van der Ploeg, LHT, Zigman, JM, Kojima, M, Kangawa, K, Smith, RG, Horvath, T & Tschöp, MH 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

TY - JOUR

T1 - Ghrelin

AU - Müller, T. D.

AU - Nogueiras, R.

AU - Andermann, M. L.

AU - Andrews, Z. B.

AU - Anker, S. D.

AU - Argente, J.

AU - Batterham, R. L.

AU - Benoit, S. C.

AU - Bowers, C. Y.

AU - Broglio, F.

AU - Casanueva, F. F.

AU - D'Alessio, D.

AU - Depoortere, I.

AU - Geliebter, A.

AU - Ghigo, E.

AU - Cole, P. A.

AU - Cowley, M.

AU - Cummings, D. E.

AU - Dagher, A.

AU - Diano, S.

AU - Dickson, S. L.

AU - Diéguez, C.

AU - Granata, R.

AU - Grill, H. J.

AU - Grove, K.

AU - Habegger, K. M.

AU - Heppner, K.

AU - Heiman, M. L.

AU - Holsen, L.

AU - Holst, B.

AU - Inui, A.

AU - Jansson, J. O.

AU - Kirchner, H.

AU - Korbonits, M.

AU - Laferrère, B.

AU - LeRoux, C. W.

AU - Lopez, M.

AU - Morin, S.

AU - Nakazato, M.

AU - Nass, R.

AU - Perez-Tilve, D.

AU - Pfluger, P. T.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Sleeman, M.

AU - Sun, Y.

AU - Sussel, L.

AU - Tong, J.

AU - Thorner, M. O.

AU - van der Lely, A. J.

AU - van der Ploeg, L. H.T.

AU - Zigman, J. M.

AU - Kojima, M.

AU - Kangawa, K.

AU - Smith, R. G.

AU - Horvath, T.

AU - Tschöp, M. H.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

AB - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

KW - Ghrelin

KW - Growth hormone segretagogue receptor

UR - https://www.scopus.com/pages/publications/84929964936

U2 - 10.1016/j.molmet.2015.03.005

DO - 10.1016/j.molmet.2015.03.005

M3 - Review article

AN - SCOPUS:84929964936

SN - 2212-8778

VL - 4

SP - 437

EP - 460

JO - Molecular Metabolism

JF - Molecular Metabolism

IS - 6

ER -

Ghrelin

Abstract

Keywords

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