@article{f7fc5d07e95842b98a061c8881f7e782,
title = "Germline variation at 8q24 and prostate cancer risk in men of European ancestry",
abstract = "Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10−15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.",
author = "{The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium} and Marco Matejcic and Saunders, {Edward J.} and Tokhir Dadaev and Brook, {Mark N.} and Kan Wang and Xin Sheng and Olama, {Ali Amin Al} and Schumacher, {Fredrick R.} and Ingles, {Sue A.} and Koveela Govindasami and Sara Benlloch and Berndt, {Sonja I.} and Demetrius Albanes and Stella Koutros and Kenneth Muir and Stevens, {Victoria L.} and Gapstur, {Susan M.} and Tangen, {Catherine M.} and Jyotsna Batra and Judith Clements and Henrik Gronberg and Nora Pashayan and Johanna Schleutker and Alicja Wolk and Catharine West and Lorelei Mucci and Peter Kraft and G{\'e}raldine Cancel-Tassin and Sorensen, {Karina D.} and Lovise Maehle and Grindedal, {Eli M.} and Strom, {Sara S.} and Neal, {David E.} and Hamdy, {Freddie C.} and Donovan, {Jenny L.} and Travis, {Ruth C.} and Hamilton, {Robert J.} and Barry Rosenstein and Lu, {Yong Jie} and Giles, {Graham G.} and Kibel, {Adam S.} and Ana Vega and Bensen, {Jeanette T.} and Manolis Kogevinas and Penney, {Kathryn L.} and Park, {Jong Y.} and Stanford, {Janet L.} and Cezary Cybulski and Nordestgaard, {B{\o}rge G.} and Kathleen Herkommer",
note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-06863-1",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
