Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

K. Flisikowski; T. Flisikowska; A. Sikorska; A. Perkowska; A. Kind; A. Schnieke; M. Switonski

doi:10.1111/vco.12186

Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

K. Flisikowski, T. Flisikowska, A. Sikorska, A. Perkowska, A. Kind, A. Schnieke, M. Switonski

TUM Emeriti of Excellence

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Cancer is a complex disease caused in part by predisposing germline gene polymorphisms. Knowledge of carcinogenesis in companion mammals (dog and cat) and some livestock species (pig and horse) is quite advanced. The prevalence of certain cancers varies by breed in these species, suggesting the presence of predisposing genetic variants in susceptible breeds. This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses. The predisposing variants in these species are discussed in the context of human germline gene polymorphisms associated with the same types of cancer.

Original language	English
Pages (from-to)	289-298
Number of pages	10
Journal	Veterinary and Comparative Oncology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1111/vco.12186
State	Published - Jun 2017

Keywords

cancer
dog
domestic mammals
germline gene polymorphism
horse
pig

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/vco.12186

Cite this

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title = "Germline gene polymorphisms predisposing domestic mammals to carcinogenesis",

abstract = "Cancer is a complex disease caused in part by predisposing germline gene polymorphisms. Knowledge of carcinogenesis in companion mammals (dog and cat) and some livestock species (pig and horse) is quite advanced. The prevalence of certain cancers varies by breed in these species, suggesting the presence of predisposing genetic variants in susceptible breeds. This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses. The predisposing variants in these species are discussed in the context of human germline gene polymorphisms associated with the same types of cancer.",

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author = "K. Flisikowski and T. Flisikowska and A. Sikorska and A. Perkowska and A. Kind and A. Schnieke and M. Switonski",

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T1 - Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

AU - Flisikowski, K.

AU - Flisikowska, T.

AU - Sikorska, A.

AU - Perkowska, A.

AU - Kind, A.

AU - Schnieke, A.

AU - Switonski, M.

PY - 2017/6

Y1 - 2017/6

N2 - Cancer is a complex disease caused in part by predisposing germline gene polymorphisms. Knowledge of carcinogenesis in companion mammals (dog and cat) and some livestock species (pig and horse) is quite advanced. The prevalence of certain cancers varies by breed in these species, suggesting the presence of predisposing genetic variants in susceptible breeds. This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses. The predisposing variants in these species are discussed in the context of human germline gene polymorphisms associated with the same types of cancer.

AB - Cancer is a complex disease caused in part by predisposing germline gene polymorphisms. Knowledge of carcinogenesis in companion mammals (dog and cat) and some livestock species (pig and horse) is quite advanced. The prevalence of certain cancers varies by breed in these species, suggesting the presence of predisposing genetic variants in susceptible breeds. This review summarizes the present understanding of germline gene polymorphisms, including BRCA1, BRCA2, MC1R, KIT, NRAS and RAD51, associated with predisposition to melanoma, mammary cancer, osteosarcoma and histiocytic sarcoma in dogs, cats, pigs and horses. The predisposing variants in these species are discussed in the context of human germline gene polymorphisms associated with the same types of cancer.

KW - cancer

KW - dog

KW - domestic mammals

KW - germline gene polymorphism

KW - horse

KW - pig

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JO - Veterinary and Comparative Oncology

JF - Veterinary and Comparative Oncology

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Germline gene polymorphisms predisposing domestic mammals to carcinogenesis

Abstract

Keywords

UN SDGs

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