Gentik des Restless-legs-syndroms

Translated title of the contribution: Genetics of the restless legs syndrome

Research output: Contribution to journalReview articlepeer-review


In genome-wide association studies genetic risk variations for the restless legs syndrome (RLS) have been identified in the genes MEIS1, BTBD9, PTPRD and LBXCOR1 / MAP2K5 genes, Carriers of one risk allele have an increased risk to suffer from RLS, Further genetic and/or non-genetic or environmental factors must additionally be present for a person to be afflicted by RLS, It is, however, not known which specific factors are involved in this process, The identified genes are involved in the development of the central nervous system, Further research is needed to show whether RLS has components of a neurological development disorder or whether the RLS genes in the adult CNS have completely different functions in relation to RLS and in the adult CNS.

Translated title of the contributionGenetics of the restless legs syndrome
Original languageGerman
Pages (from-to)524-527
Number of pages4
JournalAktuelle Neurologie
Issue number10
StatePublished - 2009
Externally publishedYes


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