Gentherapie bei gastrointestinalen tumoren am beispiel des pankreaskarzinoms: Standortbestimmung und perspektiven

Translated title of the contribution: Gene therapy in patients with gastrointestinal tumors taking pancreatic carcinomas as an example: State of the art and perspectives

J. Kleeff, H. Friess, M. Korc, M. W. Büchler

Research output: Contribution to journalReview articlepeer-review

Abstract

Gene therapy for gastrointestinal cancers has evolved from basic research to first clinical trials. This progress is due to improvements in gene transfer techniques and advances in the understanding of the molecular basis of gastrointestinal cancers. A better characterization of molecular alterations allows for the identification of molecular targets which are amenable for therapeutic interventions. Gene therapy involves the transfer of genetic material into cancer cells, which alters their neoplastic potential. Vectors used in gene transfer include viral and nonviral systems. Advances in gene transfer techniques and identification of specific molecular targets promise to lead a progress in the treatment of gastrointestinal carcinomas.

Translated title of the contributionGene therapy in patients with gastrointestinal tumors taking pancreatic carcinomas as an example: State of the art and perspectives
Original languageGerman
Pages (from-to)181-187
Number of pages7
JournalChirurgische Gastroenterologie mit Interdisziplinaren Gesprachen
Volume15
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

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