Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature

Fabrice Roux; Maria Colomé-Tatché; Cécile Edelist; René Wardenaar; Philippe Guerche; Frédéric Hospital; Vincent Colot; Ritsert C. Jansen; Frank Johannes

doi:10.1534/genetics.111.128744

Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature

Fabrice Roux, Maria Colomé-Tatché, Cécile Edelist, René Wardenaar, Philippe Guerche, Frédéric Hospital, Vincent Colot, Ritsert C. Jansen, Frank Johannes

Research output: Contribution to journal › Comment/debate

103 Scopus citations

Abstract

We extensively phenol typed 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

Original language	English
Pages (from-to)	1015-1017
Number of pages	3
Journal	Genetics
Volume	188
Issue number	4
DOIs	https://doi.org/10.1534/genetics.111.128744
State	Published - Aug 2011
Externally published	Yes

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abstract = "We extensively phenol typed 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.",

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AU - Colomé-Tatché, Maria

AU - Edelist, Cécile

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AU - Guerche, Philippe

AU - Hospital, Frédéric

AU - Colot, Vincent

AU - Jansen, Ritsert C.

AU - Johannes, Frank

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AB - We extensively phenol typed 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

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Genome-wide epigenetic perturbation jump-starts patterns of heritable variation found in nature

Abstract

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