Genome wide conditional mouse knockout resources

C. Kaloff; K. Anastassiadis; A. Ayadi; R. Baldock; J. Beig; M. C. Birling; A. Bradley; S. D.M. Brown; A. Bürger; W. Bushell; F. Chiani; F. S. Collins; B. Doe; J. T. Eppig; R. H. Finnell; C. Fletcher; P. Flicek; M. Fray; R. H. Friedel; A. Gambadoro; H. Gates; J. Hansen; Y. Herault; G. G. Hicks; A. Hörlein; M. Hrabé de Angelis; V. Iyer; P. J. de Jong; G. Koscielny; R. Kühn; P. Liu; K. C.K. Lloyd; R. G. Lopez; S. Marschall; S. Martínez; C. McKerlie; T. Meehan; H. von Melchner; M. Moore; S. A. Murray; A. Nagy; L. M.J. Nutter; G. Pavlovic; A. Pombero; H. Prosser; R. Ramirez-Solis; M. Ringwald; B. Rosen; N. Rosenthal; J. Rossant; P. Ruiz Noppinger; E. Ryder; W. C. Skarnes; J. Schick; F. Schnütgen; P. Schofield; C. Seisenberger; M. Selloum; D. Smedley; E. M. Simpson; A. F. Stewart; L. Teboul; G. P. Tocchini Valentini; D. Valenzuela; A. P. West; W. Wurst

doi:10.1016/j.ddmod.2017.08.002

Genome wide conditional mouse knockout resources

C. Kaloff
, K. Anastassiadis
, A. Ayadi
, R. Baldock
, J. Beig
, M. C. Birling
, A. Bradley
, S. D.M. Brown
, A. Bürger
, W. Bushell
, F. Chiani
, F. S. Collins
, B. Doe
, J. T. Eppig
, R. H. Finnell
, C. Fletcher
, P. Flicek
, M. Fray
, R. H. Friedel
, A. Gambadoro

H. Gates, J. Hansen, Y. Herault, G. G. Hicks, A. Hörlein, M. Hrabé de Angelis, V. Iyer, P. J. de Jong, G. Koscielny, R. Kühn, P. Liu, K. C.K. Lloyd, R. G. Lopez, S. Marschall, S. Martínez, C. McKerlie, T. Meehan, H. von Melchner, M. Moore, S. A. Murray, A. Nagy, L. M.J. Nutter, G. Pavlovic, A. Pombero, H. Prosser, R. Ramirez-Solis, M. Ringwald, B. Rosen, N. Rosenthal, J. Rossant, P. Ruiz Noppinger, E. Ryder, W. C. Skarnes, J. Schick, F. Schnütgen, P. Schofield, C. Seisenberger, M. Selloum, D. Smedley, E. M. Simpson, A. F. Stewart, L. Teboul, G. P. Tocchini Valentini, D. Valenzuela, A. P. West, W. Wurst

Chair of Developmental Genetics

Helmholtz Zentrum München German Research Center for Environmental Health
Technische Universität Dresden
ICS
University of Edinburgh, College of Medicine and Veterinary Medicine
Wellcome Trust
Medical Research Council Mammalian Genetics Unit
IMM-CNR
National Human Genome Research Institute (NHGRI)
The Jackson Laboratory
The University of Texas at Austin Dell Medical School
University of Texas at Austin
National Institutes of Health (NIH)
European Bioinformatics Institute
Mount Sinai School of Medicine
Universite de Strasbourg
Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique - Aix-Marseille University
INSERM U70
University of Manitoba
Children's Hospital Oakland Research Institute
Open Targets
Cellzome GmbH
Max Delbrück Center for Molecular Medicine
Charite Universitätsmedizin Berlin
University of California Davis
Miguel Hernández University of Elche
Centre for Phenogenomics
Klinikum der J. W. Goethe-Universität
IMPC
Mount Sinai Hospital
University of Murcia
AstraZeneca
Hospital for Sick Children and University of Toronto
University of Toronto
Metanomics Health GmbH
Barts and The London School of Medicine and Dentistry
University of British Columbia & British Columbia Children's Hospital Research Institute
University of British Columbia
Regeneron Pharmaceuticals, Inc.
German Center for Neurodegenerative Diseases (DZNE)
Munich Cluster for Systems Neurology (SyNergy)

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

Original language	English
Pages (from-to)	3-12
Number of pages	10
Journal	Drug Discovery Today: Disease Models
Volume	20
DOIs	https://doi.org/10.1016/j.ddmod.2017.08.002
State	Published - 2 Feb 2016

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10.1016/j.ddmod.2017.08.002

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Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M. C., Bradley, A., Brown, S. D. M., Bürger, A., Bushell, W., Chiani, F., Collins, F. S., Doe, B., Eppig, J. T., Finnell, R. H., Fletcher, C., Flicek, P., Fray, M., Friedel, R. H., ... Wurst, W. (2016). Genome wide conditional mouse knockout resources. Drug Discovery Today: Disease Models, 20, 3-12. https://doi.org/10.1016/j.ddmod.2017.08.002

@article{189533169f7f4574898576d641b5e35a,

title = "Genome wide conditional mouse knockout resources",

abstract = "The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.",

author = "C. Kaloff and K. Anastassiadis and A. Ayadi and R. Baldock and J. Beig and Birling, \{M. C.\} and A. Bradley and Brown, \{S. D.M.\} and A. B{\"u}rger and W. Bushell and F. Chiani and Collins, \{F. S.\} and B. Doe and Eppig, \{J. T.\} and Finnell, \{R. H.\} and C. Fletcher and P. Flicek and M. Fray and Friedel, \{R. H.\} and A. Gambadoro and H. Gates and J. Hansen and Y. Herault and Hicks, \{G. G.\} and A. H{\"o}rlein and \{Hrab{\'e} de Angelis\}, M. and V. Iyer and \{de Jong\}, \{P. J.\} and G. Koscielny and R. K{\"u}hn and P. Liu and Lloyd, \{K. C.K.\} and Lopez, \{R. G.\} and S. Marschall and S. Mart{\'i}nez and C. McKerlie and T. Meehan and \{von Melchner\}, H. and M. Moore and Murray, \{S. A.\} and A. Nagy and Nutter, \{L. M.J.\} and G. Pavlovic and A. Pombero and H. Prosser and R. Ramirez-Solis and M. Ringwald and B. Rosen and N. Rosenthal and J. Rossant and \{Ruiz Noppinger\}, P. and E. Ryder and Skarnes, \{W. C.\} and J. Schick and F. Schn{\"u}tgen and P. Schofield and C. Seisenberger and M. Selloum and D. Smedley and Simpson, \{E. M.\} and Stewart, \{A. F.\} and L. Teboul and \{Tocchini Valentini\}, \{G. P.\} and D. Valenzuela and West, \{A. P.\} and W. Wurst",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2016",

month = feb,

day = "2",

doi = "10.1016/j.ddmod.2017.08.002",

language = "English",

volume = "20",

pages = "3--12",

journal = "Drug Discovery Today: Disease Models",

issn = "1740-6757",

publisher = "Elsevier Ltd.",

}

Kaloff, C, Anastassiadis, K, Ayadi, A, Baldock, R, Beig, J, Birling, MC, Bradley, A, Brown, SDM, Bürger, A, Bushell, W, Chiani, F, Collins, FS, Doe, B, Eppig, JT, Finnell, RH, Fletcher, C, Flicek, P, Fray, M, Friedel, RH, Gambadoro, A, Gates, H, Hansen, J, Herault, Y, Hicks, GG, Hörlein, A, Hrabé de Angelis, M, Iyer, V, de Jong, PJ, Koscielny, G, Kühn, R, Liu, P, Lloyd, KCK, Lopez, RG, Marschall, S, Martínez, S, McKerlie, C, Meehan, T, von Melchner, H, Moore, M, Murray, SA, Nagy, A, Nutter, LMJ, Pavlovic, G, Pombero, A, Prosser, H, Ramirez-Solis, R, Ringwald, M, Rosen, B, Rosenthal, N, Rossant, J, Ruiz Noppinger, P, Ryder, E, Skarnes, WC, Schick, J, Schnütgen, F, Schofield, P, Seisenberger, C, Selloum, M, Smedley, D, Simpson, EM, Stewart, AF, Teboul, L, Tocchini Valentini, GP, Valenzuela, D, West, AP & Wurst, W 2016, 'Genome wide conditional mouse knockout resources', Drug Discovery Today: Disease Models, vol. 20, pp. 3-12. https://doi.org/10.1016/j.ddmod.2017.08.002

TY - JOUR

T1 - Genome wide conditional mouse knockout resources

AU - Kaloff, C.

AU - Anastassiadis, K.

AU - Ayadi, A.

AU - Baldock, R.

AU - Beig, J.

AU - Birling, M. C.

AU - Bradley, A.

AU - Brown, S. D.M.

AU - Bürger, A.

AU - Bushell, W.

AU - Chiani, F.

AU - Collins, F. S.

AU - Doe, B.

AU - Eppig, J. T.

AU - Finnell, R. H.

AU - Fletcher, C.

AU - Flicek, P.

AU - Fray, M.

AU - Friedel, R. H.

AU - Gambadoro, A.

AU - Gates, H.

AU - Hansen, J.

AU - Herault, Y.

AU - Hicks, G. G.

AU - Hörlein, A.

AU - Hrabé de Angelis, M.

AU - Iyer, V.

AU - de Jong, P. J.

AU - Koscielny, G.

AU - Kühn, R.

AU - Liu, P.

AU - Lloyd, K. C.K.

AU - Lopez, R. G.

AU - Marschall, S.

AU - Martínez, S.

AU - McKerlie, C.

AU - Meehan, T.

AU - von Melchner, H.

AU - Moore, M.

AU - Murray, S. A.

AU - Nagy, A.

AU - Nutter, L. M.J.

AU - Pavlovic, G.

AU - Pombero, A.

AU - Prosser, H.

AU - Ramirez-Solis, R.

AU - Ringwald, M.

AU - Rosen, B.

AU - Rosenthal, N.

AU - Rossant, J.

AU - Ruiz Noppinger, P.

AU - Ryder, E.

AU - Skarnes, W. C.

AU - Schick, J.

AU - Schnütgen, F.

AU - Schofield, P.

AU - Seisenberger, C.

AU - Selloum, M.

AU - Smedley, D.

AU - Simpson, E. M.

AU - Stewart, A. F.

AU - Teboul, L.

AU - Tocchini Valentini, G. P.

AU - Valenzuela, D.

AU - West, A. P.

AU - Wurst, W.

PY - 2016/2/2

Y1 - 2016/2/2

N2 - The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

AB - The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 C57BL/6 cre-inducible mouse strains. Complementing the cre-driver resource, a collection comprising 27 rAAVs expressing cre in a tissue-specific manner has also been produced. All resources are easily accessible from the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds enabling the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

UR - https://www.scopus.com/pages/publications/85029227398

U2 - 10.1016/j.ddmod.2017.08.002

DO - 10.1016/j.ddmod.2017.08.002

M3 - Review article

AN - SCOPUS:85029227398

SN - 1740-6757

VL - 20

SP - 3

EP - 12

JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

ER -

Genome wide conditional mouse knockout resources

Abstract

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