@article{886e7dd506624227ab5698be7eb232a9,
title = "Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate",
abstract = "We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 × 10-8, relative risk in homozygotes = 1.84, 95% CI 1.342.53) and 10q25.3 (rs7078160, combined P = 1.92 × 10-8, relative risk in homozygotes = 2.17, 95% CI 1.323.56).",
author = "Elisabeth Mangold and Ludwig, {Kerstin U.} and Stefanie Birnbaum and Carlotta Baluardo and Melissa Ferrian and Stefan Herms and Heiko Reutter and {De Assis}, {Nilma Almeida} and Chawa, {Taofik Al} and Manuel Mattheisen and Michael Steffens and Sandra Barth and Nadine Kluck and Anna Paul and Jessica Becker and Carola Lauster and G{\"u}l Schmidt and Bert Braumann and Martin Scheer and Reich, {Rudolf H.} and Alexander Hemprich and Simone P{\"o}tzsch and Bettina Blaumeiser and Susanne Moebus and Michael Krawczak and Stefan Schreiber and Thomas Meitinger and Wichmann, {Hans Erich} and Steegers-Theunissen, {Regine P.} and Kramer, {Franz Josef} and Sven Cichon and Peter Propping and Wienker, {Thomas F.} and Michael Knapp and Michele Rubini and Mossey, {Peter A.} and Per Hoffmann and N{\"o}then, {Markus M.}",
note = "Funding Information: We thank all affected individuals and their families for their participation in this study as well as the German support group for people with cleft lip and/or palate (Deutsche Selbsthilfevereinigung f{\"u}r LippenGaumenFehlbildungen e.V.). We acknowledge our collaborating clinical partners, all colleagues who contributed to the European Collaboration on Craniofacial Anomalies (EUROCRAN) project, our laboratory technicians and colleagues responsible for database management (for a complete list of all individuals see Supplementary Note). The study was supported by the Deutsche Forschungsgemeinschaft (FOR 423 and individual grants MA 2546/31, KR 1912/71, NO 246/61 and WI 1555/51). The Heinz Nixdorf Recall cohort was established with the generous support of the Heinz Nixdorf Foundation, Germany (Chairman: G. Schmidt). POPGEN biobank is financed by the local Ministry of Science, Economy and Transport of SchleswigHolstein, Germany. The Kooperative Gesundheitforschung in der Region Augsburg (KORA) research platform was initiated and financed by the Helmholtz Center Munich, German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research and by the state of Bavaria. The work of KORA is supported by the German Federal Ministry of Education and Research (BMBF) in the context of the German National Genome Research Network (NGFN2 and NGFNplus). The EUROCRAN study was supported by the European Commission FP5 (contract no. QLG1CT2000-01019), and the ITALCLEFT study was supported by a FAR2008 grant from the University of Ferrara, Italy. N.A.d.A. is supported by the Conselho Nacional de Pesquisa (CNPq), Brasil. T.A.C. is supported by a grant from the Ministry of Higher Education, Syrian Arab Republic. Additional acknowledgments are found in the Supplementary Note.",
year = "2010",
month = jan,
doi = "10.1038/ng.506",
language = "English",
volume = "42",
pages = "24--26",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "1",
}