TY - JOUR
T1 - Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
AU - Anorexia Nervosa Genetics Initiative
AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium
AU - Watson, Hunna J.
AU - Yilmaz, Zeynep
AU - Thornton, Laura M.
AU - Hübel, Christopher
AU - Coleman, Jonathan R.I.
AU - Gaspar, Héléna A.
AU - Bryois, Julien
AU - Hinney, Anke
AU - Leppä, Virpi M.
AU - Mattheisen, Manuel
AU - Medland, Sarah E.
AU - Ripke, Stephan
AU - Yao, Shuyang
AU - Giusti-Rodríguez, Paola
AU - Hanscombe, Ken B.
AU - Purves, Kirstin L.
AU - Adan, Roger A.H.
AU - Alfredsson, Lars
AU - Ando, Tetsuya
AU - Andreassen, Ole A.
AU - Baker, Jessica H.
AU - Berrettini, Wade H.
AU - Boehm, Ilka
AU - Boni, Claudette
AU - Perica, Vesna Boraska
AU - Buehren, Katharina
AU - Burghardt, Roland
AU - Cassina, Matteo
AU - Cichon, Sven
AU - Clementi, Maurizio
AU - Cone, Roger D.
AU - Courtet, Philippe
AU - Crow, Scott
AU - Crowley, James J.
AU - Danner, Unna N.
AU - Davis, Oliver S.P.
AU - de Zwaan, Martina
AU - Dedoussis, George
AU - Degortes, Daniela
AU - DeSocio, Janiece E.
AU - Dick, Danielle M.
AU - Dikeos, Dimitris
AU - Dina, Christian
AU - Dmitrzak-Weglarz, Monika
AU - Docampo, Elisa
AU - Duncan, Laramie E.
AU - Egberts, Karin
AU - Ehrlich, Stefan
AU - Escaramís, Geòrgia
AU - Zeggini, Eleftheria
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2–4, with twin-based heritability estimates of 50–60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
AB - Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9–4% of women and 0.3% of men2–4, with twin-based heritability estimates of 50–60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
UR - https://www.scopus.com/pages/publications/85068455956
U2 - 10.1038/s41588-019-0439-2
DO - 10.1038/s41588-019-0439-2
M3 - Article
C2 - 31308545
AN - SCOPUS:85068455956
SN - 1061-4036
VL - 51
SP - 1207
EP - 1214
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -