Genome-wide association studies of atrial fibrillation: Past, present, and future

Moritz F. Sinner; Patrick T. Ellinor; Thomas Meitinger; Emelia J. Benjamin; Stefan Kääb

doi:10.1093/cvr/cvr001

Genome-wide association studies of atrial fibrillation: Past, present, and future

Moritz F. Sinner
, Patrick T. Ellinor
, Thomas Meitinger
, Emelia J. Benjamin
, Stefan Kääb

Medicine and Health

Ludwig-Maximilians-Universität München
Massachusetts General Hospital
Framingham Heart Study
Helmholtz Zentrum München German Research Center for Environmental Health
Boston University
Boston University School of Medicine

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

Abstract

Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF. Published on behalf of the European Society of Cardiology. All rights reserved.

Original language	English
Pages (from-to)	701-709
Number of pages	9
Journal	Cardiovascular Research
Volume	89
Issue number	4
DOIs	https://doi.org/10.1093/cvr/cvr001
State	Published - 1 Mar 2011

Keywords

Arrhythmia
Atrial fibrillation
Genetics
Genome-wide association study
Single nucleotide polymorphism

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10.1093/cvr/cvr001

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title = "Genome-wide association studies of atrial fibrillation: Past, present, and future",

abstract = "Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF. Published on behalf of the European Society of Cardiology. All rights reserved.",

keywords = "Arrhythmia, Atrial fibrillation, Genetics, Genome-wide association study, Single nucleotide polymorphism",

author = "Sinner, \{Moritz F.\} and Ellinor, \{Patrick T.\} and Thomas Meitinger and Benjamin, \{Emelia J.\} and Stefan K{\"a}{\"a}b",

note = "Funding Information: This work was supported by the National Institutes of Health (1R01HL092577 to E.J.B. and P.T.E.; 1RC1HL101056, 1R01HL102214 to E.J.B; 1R01HL104156, 5R21DA027021, 1K24HL105780 to P.T.E.); Bundesministerium f{\"u}r Bildung und Forschung BMBF (German Competence Network on AF AFNET 01 GI 0204/N, German National Genome Research Network NGFN 01GS0499, 01GS0838 to S.K.; Leducq Foundation (07-CVD 03 to E.J.B., P.T.E. and S.K.); LMU Excellence Initiative to S.K.; LMU Research grant (F{\"o}FoLe 557/569 to M.F.S.). M.F.S. is supported by the German Heart Foundation.",

year = "2011",

month = mar,

day = "1",

doi = "10.1093/cvr/cvr001",

language = "English",

volume = "89",

pages = "701--709",

journal = "Cardiovascular Research",

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T2 - Past, present, and future

AU - Sinner, Moritz F.

AU - Ellinor, Patrick T.

AU - Meitinger, Thomas

AU - Benjamin, Emelia J.

AU - Kääb, Stefan

N1 - Funding Information: This work was supported by the National Institutes of Health (1R01HL092577 to E.J.B. and P.T.E.; 1RC1HL101056, 1R01HL102214 to E.J.B; 1R01HL104156, 5R21DA027021, 1K24HL105780 to P.T.E.); Bundesministerium für Bildung und Forschung BMBF (German Competence Network on AF AFNET 01 GI 0204/N, German National Genome Research Network NGFN 01GS0499, 01GS0838 to S.K.; Leducq Foundation (07-CVD 03 to E.J.B., P.T.E. and S.K.); LMU Excellence Initiative to S.K.; LMU Research grant (FöFoLe 557/569 to M.F.S.). M.F.S. is supported by the German Heart Foundation.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF. Published on behalf of the European Society of Cardiology. All rights reserved.

AB - Genome-wide association studies (GWAS) for atrial fibrillation (AF) have identified three distinct genetic loci on chromosomes 1q21, 4q25, and 16q22 that are associated with the arrhythmia. Susceptibility loci also have been identified by GWAS for PR interval duration, a quantitative phenotype related to AF. In this review article, we have sought to summarize the latest findings for population-based genetic studies of AF, to highlight ongoing functional studies, and to explore the future directions of genetic research on AF. Published on behalf of the European Society of Cardiology. All rights reserved.

KW - Arrhythmia

KW - Atrial fibrillation

KW - Genetics

KW - Genome-wide association study

KW - Single nucleotide polymorphism

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SP - 701

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JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 4

ER -

Genome-wide association studies of atrial fibrillation: Past, present, and future

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Keywords

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