TY - JOUR
T1 - Genome-wide association scans for Type 2 diabetes
T2 - new insights into biology and therapy
AU - McCarthy, Mark I.
AU - Zeggini, Eleftheria
PY - 2007/12
Y1 - 2007/12
N2 - Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 diabetes has proven a challenging task, rewarded, until recently, with only limited success. However, the field of Type 2 diabetes genetics has been transformed over the past few months, with the publication of six genome-wide association scans, leading to the establishment of novel genomic regions that harbour disease susceptibility loci. Here, we provide an overview of the main recent findings and discuss their significance in providing biological insights and their translational implications.
AB - Type 2 diabetes is a complex, multifactorial disease, for which genetic and environmental factors jointly determine susceptibility. Disentangling the genetic aetiology of Type 2 diabetes has proven a challenging task, rewarded, until recently, with only limited success. However, the field of Type 2 diabetes genetics has been transformed over the past few months, with the publication of six genome-wide association scans, leading to the establishment of novel genomic regions that harbour disease susceptibility loci. Here, we provide an overview of the main recent findings and discuss their significance in providing biological insights and their translational implications.
UR - http://www.scopus.com/inward/record.url?scp=36448950162&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2007.10.008
DO - 10.1016/j.tips.2007.10.008
M3 - Short survey
C2 - 17997168
AN - SCOPUS:36448950162
SN - 0165-6147
VL - 28
SP - 598
EP - 601
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 12
ER -
