Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Philip E. Stuart; Rajan P. Nair; Eva ELinghaus; Jun Ding; Trilokraj Tejasvi; Johan E. GudjonSon; Yun Li; Stephan Weidinger; Bernadete Eberlein; Christian Gieger; H. Erich WichmaN; Manfred Kunz; Robert Ike; Gerald G. Krueger; Ane M. Bowcock; Ulrich Mrowietz; Henry W. Lim; John J. VOrhEs; Gonçalo R. Abecasis; Michael Weichenthal; Andre Franke; Proton Rahman; Dafna D. Gladman; James T. Elder

doi:10.1038/ng.693

Genome-wide asociation analysis identifies three psoriasis susceptibility loci

Philip E. Stuart, Rajan P. Nair, Eva ELinghaus, Jun Ding, Trilokraj Tejasvi, Johan E. GudjonSon, Yun Li, Stephan Weidinger, Bernadete Eberlein, Christian Gieger, H. Erich WichmaN, Manfred Kunz, Robert Ike, Gerald G. Krueger, Ane M. Bowcock, Ulrich Mrowietz, Henry W. Lim, John J. VOrhEs, Gonçalo R. Abecasis, Michael WeichenthalAndre Franke, Proton Rahman, Dafna D. Gladman, James T. Elder

Department of Dermatology and Allergology

Research output: Contribution to journal › Article › peer-review

275 Scopus citations

Abstract

We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10^-11), one at FBXL19 (rs10782001, combined P = 9-10^-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10^-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10^-5; rs10782001, combined P = 4-10^-8; and rs12586317, combined P = 6-10^-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10^-8; rs10782001, combined P = 2-10^-6; and rs12586317, combined P = 1-10^-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10^-7).

Original language	English
Pages (from-to)	1000-1004
Number of pages	5
Journal	Nature Genetics
Volume	42
Issue number	11
DOIs	https://doi.org/10.1038/ng.693
State	Published - Nov 2010

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Stuart, P. E., Nair, R. P., ELinghaus, E., Ding, J., Tejasvi, T., GudjonSon, J. E., Li, Y., Weidinger, S., Eberlein, B., Gieger, C., WichmaN, H. E., Kunz, M., Ike, R., Krueger, G. G., Bowcock, A. M., Mrowietz, U., Lim, H. W., VOrhEs, J. J., Abecasis, G. R., ... Elder, J. T. (2010). Genome-wide asociation analysis identifies three psoriasis susceptibility loci. Nature Genetics, 42(11), 1000-1004. https://doi.org/10.1038/ng.693

@article{a10d87990ff949dc949f703128b724c9,

title = "Genome-wide asociation analysis identifies three psoriasis susceptibility loci",

abstract = "We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).",

author = "Stuart, {Philip E.} and Nair, {Rajan P.} and Eva ELinghaus and Jun Ding and Trilokraj Tejasvi and GudjonSon, {Johan E.} and Yun Li and Stephan Weidinger and Bernadete Eberlein and Christian Gieger and WichmaN, {H. Erich} and Manfred Kunz and Robert Ike and Krueger, {Gerald G.} and Bowcock, {Ane M.} and Ulrich Mrowietz and Lim, {Henry W.} and VOrhEs, {John J.} and Abecasis, {Gon{\c c}alo R.} and Michael Weichenthal and Andre Franke and Proton Rahman and Gladman, {Dafna D.} and Elder, {James T.}",

year = "2010",

month = nov,

doi = "10.1038/ng.693",

language = "English",

volume = "42",

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Stuart, PE, Nair, RP, ELinghaus, E, Ding, J, Tejasvi, T, GudjonSon, JE, Li, Y, Weidinger, S, Eberlein, B, Gieger, C, WichmaN, HE, Kunz, M, Ike, R, Krueger, GG, Bowcock, AM, Mrowietz, U, Lim, HW, VOrhEs, JJ, Abecasis, GR, Weichenthal, M, Franke, A, Rahman, P, Gladman, DD & Elder, JT 2010, 'Genome-wide asociation analysis identifies three psoriasis susceptibility loci', Nature Genetics, vol. 42, no. 11, pp. 1000-1004. https://doi.org/10.1038/ng.693

TY - JOUR

T1 - Genome-wide asociation analysis identifies three psoriasis susceptibility loci

AU - Stuart, Philip E.

AU - Nair, Rajan P.

AU - ELinghaus, Eva

AU - Ding, Jun

AU - Tejasvi, Trilokraj

AU - GudjonSon, Johan E.

AU - Li, Yun

AU - Weidinger, Stephan

AU - Eberlein, Bernadete

AU - Gieger, Christian

AU - WichmaN, H. Erich

AU - Kunz, Manfred

AU - Ike, Robert

AU - Krueger, Gerald G.

AU - Bowcock, Ane M.

AU - Mrowietz, Ulrich

AU - Lim, Henry W.

AU - VOrhEs, John J.

AU - Abecasis, Gonçalo R.

AU - Weichenthal, Michael

AU - Franke, Andre

AU - Rahman, Proton

AU - Gladman, Dafna D.

AU - Elder, James T.

PY - 2010/11

Y1 - 2010/11

N2 - We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).

AB - We carried out a meta-analysis of two recent psoriasis genome-wide asociation studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were foLowed up in a thrE-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified thrE new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4-10-11), one at FBXL19 (rs10782001, combined P = 9-10-10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2-10-8). AL thrE loci were also aSociated with psoriatic arthritis (rs4795067, combined P = 1-10-5; rs10782001, combined P = 4-10-8; and rs12586317, combined P = 6-10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1-10-8; rs10782001, combined P = 2-10-6; and rs12586317, combined P = 1-10-6). We also replicated a recently identified asociation signal near RNF114 (rs495337, combined P = 2-10-7).

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U2 - 10.1038/ng.693

DO - 10.1038/ng.693

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VL - 42

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JO - Nature Genetics

JF - Nature Genetics

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ER -

Genome-wide asociation analysis identifies three psoriasis susceptibility loci

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