Genome evolution and protein-protein interactions: A quantitative study

P. Pagel, D. Frishman

Research output: Contribution to journalArticlepeer-review


Contradictory results have been obtained in previous studies that analyzed the putative relationship between protein conservation and the number of interaction partners. In our study we approach this question at the whole-protein level, and find interacting proteins significantly more likely to be preserved in evolution than non-interacting proteins. At least for proteins with up to 10 interaction partners we find a correlation between interactivity and conservation probability. In contrast to the previously described strong bias toward same-function proteins, no such preference was found for conservation of interaction pairs.

Original languageEnglish
Pages (from-to)S105-S109
Issue numberSUPPL1
StatePublished - 2003
Externally publishedYes


  • Comparative genomics
  • Evolution
  • Protein-protein interactions


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