TY - JOUR
T1 - Genome editing redefines precision medicine in the cardiovascular field
AU - Dzilic, Elda
AU - Lahm, Harald
AU - Dreßen, Martina
AU - Deutsch, Marcus André
AU - Lange, Rüdiger
AU - Wu, Sean M.
AU - Krane, Markus
AU - Doppler, Stefanie A.
N1 - Publisher Copyright:
© 2018 Elda Dzilic et al.
PY - 2018
Y1 - 2018
N2 - Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies.
AB - Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies.
UR - http://www.scopus.com/inward/record.url?scp=85054434305&partnerID=8YFLogxK
U2 - 10.1155/2018/4136473
DO - 10.1155/2018/4136473
M3 - Review article
AN - SCOPUS:85054434305
SN - 1687-9678
VL - 2018
JO - Stem Cells International
JF - Stem Cells International
M1 - 4136473
ER -
