Genetics of sleep and sleep disorders

M. Kimura, J. Winkelmann

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Genetic factors affect sleep. Studies in twin pairs demonstrate that the strong hereditary influences on sleep architecture and some sleep disorders are transmitted through families. Evidence like this strongly suggests that sleep regulation receives significant influence from genetic factors. Although recent molecular technologies have revealed evidence that genetic traits or gene products trigger particular changes in sleep electroencephalogram activity, we are still far from finding candidate genes or multiple mutations responsible for individual sleep disorders. Sleep is a very complex phenotype. Genetic susceptibility and environmental factors should be also considered as contributors to sleep phenotype. The aim of this review is to present a current summary and future prospects for genetic studies on sleep and selected sleep-associated disorders.

Original languageEnglish
Pages (from-to)1216-1226
Number of pages11
JournalCellular and Molecular Life Sciences
Volume64
Issue number10
DOIs
StatePublished - May 2007

Keywords

  • Chromosome
  • Electroencephalography (EEG)
  • Familial sleep disorders
  • Genotype
  • Heritability
  • Inbread mice
  • Mutations
  • Polymorphism

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