TY - JOUR
T1 - Genetically modified pigs to model human diseases
AU - Flisikowska, Tatiana
AU - Kind, Alexander
AU - Schnieke, Angelika
PY - 2014/2
Y1 - 2014/2
N2 - Genetically modified mice are powerful tools to investigate the molecular basis of many human diseases. Mice are, however, of limited value for preclinical studies, because they differ significantly from humans in size, general physiology, anatomy and lifespan. Considerable efforts are, thus, being made to develop alternative animal models for a range of human diseases. These promise powerful new resources that will aid the development of new diagnostics, medicines and medical procedures. Here, we provide a comprehensive review of genetically modified porcine models described in the scientific literature: various cancers, cystic fibrosis, Duchenne muscular dystrophy, autosomal polycystic kidney disease, Huntington's disease, spinal muscular atrophy, haemophilia A, X-linked severe combined immunodeficiency, retinitis pigmentosa, Stargardt disease, Alzheimer's disease, various forms of diabetes mellitus and cardiovascular diseases.
AB - Genetically modified mice are powerful tools to investigate the molecular basis of many human diseases. Mice are, however, of limited value for preclinical studies, because they differ significantly from humans in size, general physiology, anatomy and lifespan. Considerable efforts are, thus, being made to develop alternative animal models for a range of human diseases. These promise powerful new resources that will aid the development of new diagnostics, medicines and medical procedures. Here, we provide a comprehensive review of genetically modified porcine models described in the scientific literature: various cancers, cystic fibrosis, Duchenne muscular dystrophy, autosomal polycystic kidney disease, Huntington's disease, spinal muscular atrophy, haemophilia A, X-linked severe combined immunodeficiency, retinitis pigmentosa, Stargardt disease, Alzheimer's disease, various forms of diabetes mellitus and cardiovascular diseases.
KW - Disease model
KW - Gene targeting
KW - Pig
KW - Swine
KW - TALENs
KW - Transgenic
KW - ZFNs
UR - http://www.scopus.com/inward/record.url?scp=84893618608&partnerID=8YFLogxK
U2 - 10.1007/s13353-013-0182-9
DO - 10.1007/s13353-013-0182-9
M3 - Review article
C2 - 24234401
AN - SCOPUS:84893618608
SN - 1234-1983
VL - 55
SP - 53
EP - 64
JO - Journal of Applied Genetics
JF - Journal of Applied Genetics
IS - 1
ER -