Genetically controlled MRI contrast mechanisms and their prospects in systems neuroscience research

Gil G. Westmeyer, Alan Jasanoff

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Application of MRI contrast agents to neural systems research is complicated by the need to deliver agents past the blood-brain barrier or into cells, and the difficulty of targeting agents to specific brain structures or cell types. In the future, these barriers may be wholly or partially overcome using genetic methods for producing and directing MRI contrast. Here we review MRI contrast mechanisms that have used gene expression to manipulate MRI signal in cultured cells or in living animals. We discuss both fully genetic systems involving endogenous biosynthesis of contrast agents, and semi-genetic systems in which expressed proteins influence the localization or activity of exogenous contrast agents. We close by considering which contrast-generating mechanisms might be most suitable for applications in neuroscience, and we ask how genetic control machinery could be productively combined with existing molecular agents to enable next-generation neuroimaging experiments.

Original languageEnglish
Pages (from-to)1004-1010
Number of pages7
JournalMagnetic Resonance Imaging
Volume25
Issue number6
DOIs
StatePublished - Jul 2007
Externally publishedYes

Keywords

  • Ferritin
  • Hemoglobin
  • LacZ
  • MRI contrast agent
  • Magnetic resonance imaging
  • Nanoparticles
  • Reporter genes
  • Transferrin receptor
  • fMRI
  • β-Galactosidase

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