Genetic analysis of susceptibility to diabetes mellitus in F2-hybrids between diabetes-prone BB and various MHC-recombinant congenic rat strains

Eberhard Günther; Ulrich Kiesel; Hubert Kolb; Michael Krawczak; Ellen Rothermel; Wolfgang Wurst

doi:10.1016/0896-8411(91)90165-9

Genetic analysis of susceptibility to diabetes mellitus in F₂-hybrids between diabetes-prone BB and various MHC-recombinant congenic rat strains

Eberhard Günther, Ulrich Kiesel, Hubert Kolb, Michael Krawczak, Ellen Rothermel, Wolfgang Wurst

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Abstract

The occurrence of diabetes mellitus was analysed in F₂ hybrids bred from diabetic BB male rats and females of congenic rat strains carrying different major histocompatibility (RT1) haplotypes on the common LEW strain genetic background. Permissiveness for the disease in BB rats is probably determined by class II genes of the RT1 complex, which are also present in normal rats. Class I and class III genes, notably the Hsp70 genes in the class III region, do not appear to be involved. Among the diabetic F₂ hybrids, about 90% are shown by DNA analysis to be homozygous for the class II genes of the permissive RT1 haplotype. The segregation patterns are in accord with the action of two independent recessive genes, one of them being RT1-linked.

Original language	English
Pages (from-to)	543-551
Number of pages	9
Journal	Journal of Autoimmunity
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/0896-8411(91)90165-9
State	Published - Jun 1991
Externally published	Yes

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abstract = "The occurrence of diabetes mellitus was analysed in F2 hybrids bred from diabetic BB male rats and females of congenic rat strains carrying different major histocompatibility (RT1) haplotypes on the common LEW strain genetic background. Permissiveness for the disease in BB rats is probably determined by class II genes of the RT1 complex, which are also present in normal rats. Class I and class III genes, notably the Hsp70 genes in the class III region, do not appear to be involved. Among the diabetic F2 hybrids, about 90% are shown by DNA analysis to be homozygous for the class II genes of the permissive RT1 haplotype. The segregation patterns are in accord with the action of two independent recessive genes, one of them being RT1-linked.",

author = "Eberhard G{\"u}nther and Ulrich Kiesel and Hubert Kolb and Michael Krawczak and Ellen Rothermel and Wolfgang Wurst",

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AU - Kiesel, Ulrich

AU - Kolb, Hubert

AU - Krawczak, Michael

AU - Rothermel, Ellen

AU - Wurst, Wolfgang

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Genetic analysis of susceptibility to diabetes mellitus in F₂-hybrids between diabetes-prone BB and various MHC-recombinant congenic rat strains

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