Genetic analysis of MAPT haplotype diversity in frontotemporal dementia

S. M. Laws; P. Friedrich; J. Diehl-Schmid; J. Müller; B. Ibach; J. Bäuml; T. Eisele; H. Förstl; A. Kurz; M. Riemenschneider

doi:10.1016/j.neurobiolaging.2007.02.019

Genetic analysis of MAPT haplotype diversity in frontotemporal dementia

S. M. Laws, P. Friedrich, J. Diehl-Schmid, J. Müller, B. Ibach, J. Bäuml, T. Eisele, H. Förstl, A. Kurz, M. Riemenschneider

Department of Psychiatry and Psychotherapy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.

Original language	English
Pages (from-to)	1276-1278
Number of pages	3
Journal	Neurobiology of Aging
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.neurobiolaging.2007.02.019
State	Published - Aug 2008

Keywords

Frontotemporal dementia
MAPT
Microtubule-associated protein tau

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10.1016/j.neurobiolaging.2007.02.019

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title = "Genetic analysis of MAPT haplotype diversity in frontotemporal dementia",

abstract = "The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.",

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AU - Laws, S. M.

AU - Friedrich, P.

AU - Diehl-Schmid, J.

AU - Müller, J.

AU - Ibach, B.

AU - Bäuml, J.

AU - Eisele, T.

AU - Förstl, H.

AU - Kurz, A.

AU - Riemenschneider, M.

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AB - The H1 haplotype of the tau gene, MAPT, has been linked to the sporadic tauopathies corticobasal degeneration and progressive supranuclear palsy; however, there have been inconsistent findings regarding association with frontotemporal dementia (FTD). We investigated MAPT haplotype diversity, in 171 sporadic FTD and 186 healthy controls individuals, and report no single marker or haplotype association with increased risk or changes in age at onset. These findings do not support an association of MAPT with FTD but do not rule out its association with other tauopathies.

KW - Frontotemporal dementia

KW - MAPT

KW - Microtubule-associated protein tau

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Genetic analysis of MAPT haplotype diversity in frontotemporal dementia

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Keywords

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