TY - JOUR
T1 - Genes predict village of origin in rural Europe
AU - O'Dushlaine, Colm
AU - McQuillan, Ruth
AU - Weale, Michael E.
AU - Crouch, Daniel J.M.
AU - Johansson, Åsa
AU - Aulchenko, Yurii
AU - Franklin, Christopher S.
AU - Polašek, Ozren
AU - Fuchsberger, Christian
AU - Corvin, Aiden
AU - Hicks, Andrew A.
AU - Vitart, Veronique
AU - Hayward, Caroline
AU - Wild, Sarah H.
AU - Meitinger, Thomas
AU - Van Duijn, Cornelia M.
AU - Gyllensten, Ulf
AU - Wright, Alan F.
AU - Campbell, Harry
AU - Pramstaller, Peter P.
AU - Rudan, Igor
AU - Wilson, James F.
N1 - Funding Information:
We thank the study volunteers in each population. EUROSPAN (European Special Populations Research Network) was supported by European Union FP6 Grant number 018947 (LSHG-CT-2006-01947). For the MICROS study, we thank the primary-care practitioners and the Department of Laboratory Medicine, Hospital of Silandro. The study was supported by the Ministry of Health and Department of Educational Assistance, University and Research of the Autonomous Province of Bolzano and the South Tyrolean Sparkasse Foundation. ORCADES was supported by the Scottish Government Chief Scientist Office and the Royal Society. DNA extractions were performed at the Wellcome Trust Clinical Research Facility (WTCRF) in Edinburgh. We acknowledge the invaluable contributions of L Anderson and the research nurses and the administrative team in Edinburgh. The Croatian study was supported through grants from the Medical Research Council, UK, and the Ministry of Science, Education and Sport of the Republic of Croatia (number 108-1080315-0302). We thank Professor P Rudan and the staff of the Institute for Anthropological Research in Zagreb; genotyping of the Croatian samples was carried out at the WTCRF, Edinburgh. CO’D was funded by a postdoctoral fellowship from the Irish Research Council for Science Engineering and Technology and AC from Science Foundation Ireland.
PY - 2010/11
Y1 - 2010/11
N2 - The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.
AB - The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals.
KW - genome-wide genotyping
KW - population structure
KW - principal components
UR - https://www.scopus.com/pages/publications/77958470124
U2 - 10.1038/ejhg.2010.92
DO - 10.1038/ejhg.2010.92
M3 - Article
C2 - 20571506
AN - SCOPUS:77958470124
SN - 1018-4813
VL - 18
SP - 1269
EP - 1270
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 11
ER -