TY - JOUR
T1 - Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual
AU - Wang, Xianming
AU - Malinowski, Andrzej R.
AU - Beckenbauer, J.
AU - Siehler, Johanna
AU - Blöchinger, Anna
AU - Meitinger, Thomas
AU - Häring, Hans Ulrich
AU - Staiger, Harald
AU - Burtscher, Ingo
AU - Lickert, H.
N1 - Publisher Copyright:
© 2019
PY - 2019/8
Y1 - 2019/8
N2 - Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic β-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be useful to test differentiation protocols towards β-cell as well as other cell types and will also serve as a control for drug development and disease modelling studies.
AB - Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic β-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be useful to test differentiation protocols towards β-cell as well as other cell types and will also serve as a control for drug development and disease modelling studies.
UR - http://www.scopus.com/inward/record.url?scp=85070517938&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2019.101531
DO - 10.1016/j.scr.2019.101531
M3 - Article
C2 - 31419739
AN - SCOPUS:85070517938
SN - 1873-5061
VL - 39
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 101531
ER -