TY - JOUR
T1 - Generation and characterization of dickkopf3 mutant mice
AU - Del Barco Barrantes, Ivan
AU - Montero-Pedrazuela, Ana
AU - Guadaño-Ferraz, Ana
AU - Obregon, Maria Jesus
AU - Martinez De Mena, Raquel
AU - Gailus-Durner, Valérie
AU - Fuchs, Helmut
AU - Franz, Tobias J.
AU - Kalaydjiev, Svetoslav
AU - Klempt, Martina
AU - Hölter, Sabine
AU - Rathkolb, Birgit
AU - Reinhard, Claudia
AU - De Escobar, Gabriella Morreale
AU - Bernal, Juan
AU - Busch, Dirk H.
AU - Wurst, Wolfgang
AU - Wolf, Eckhard
AU - Schulz, Holger
AU - Shtrom, Svetlana
AU - Greiner, Erich
AU - De Angelis, Martin Hrabé
AU - Westphal, Heiner
AU - Niehrs, Christof
PY - 2006/3
Y1 - 2006/3
N2 - dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Bkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.
AB - dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Bkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, as well as thyroid hormone levels. Mutant mice are euthyroid, and the data do not support a relationship of dkk3 with thyroid hormone metabolism. Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity.
UR - https://www.scopus.com/pages/publications/33644746621
U2 - 10.1128/MCB.26.6.2317-2326.2006
DO - 10.1128/MCB.26.6.2317-2326.2006
M3 - Article
C2 - 16508007
AN - SCOPUS:33644746621
SN - 0270-7306
VL - 26
SP - 2317
EP - 2326
JO - Molecular and Cellular Biology
JF - Molecular and Cellular Biology
IS - 6
ER -