TY - JOUR
T1 - GDF-15/MIC-1 a novel member of the TGF-β superfamily
AU - Strelau, J.
AU - Böttner, M.
AU - Lingor, P.
AU - Suter-Crazzolara, C.
AU - Galter, D.
AU - Jaszai, J.
AU - Sullivan, A.
AU - Schober, A.
AU - Krieglstein, K.
AU - Unsicker, K.
PY - 2000
Y1 - 2000
N2 - We have cloned, expressed, and raised antibodies against a novel member of the TGF-β superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-β superfamily and does not belong to one of the known TGF-β subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
AB - We have cloned, expressed, and raised antibodies against a novel member of the TGF-β superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-β superfamily and does not belong to one of the known TGF-β subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
UR - http://www.scopus.com/inward/record.url?scp=0034522731&partnerID=8YFLogxK
M3 - Article
C2 - 11205146
AN - SCOPUS:0034522731
SN - 0303-6995
SP - 273
EP - 276
JO - Journal of Neural Transmission, Supplement
JF - Journal of Neural Transmission, Supplement
IS - 60
ER -
