Gastrointestinal Signals: Stimulation

R. Nogueiras; P. Wiedmer; D. Perez-Tilve; S. J. Caton; M. H. Tschöp

doi:10.1016/B978-008045046-9.00443-5

Gastrointestinal Signals: Stimulation

R. Nogueiras, P. Wiedmer, D. Perez-Tilve, S. J. Caton, M. H. Tschöp

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

While providing digestion of food and absorption of nutrients, the gastrointestinal (GI) tract also possesses endocrine activity. Originally several GI peptides contributing to termination of food intake were identified. However, the GI tract also secretes orexigenic peptides. Among those are ?-casomorphin, motilin, and ghrelin. Ghrelin represents the most potent peripherally secreted orexigen and has pleiotropic effects on several tissues turning it into an important regulator of energy balance and glucose homeostasis. The orexigenic effects of these three peptides are mediated by different pathways through the central nervous system. This article summarizes through which mechanisms ?-casomorphin, motilin, and ghrelin stimulate food intake and which central pathways are involved.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	577-581
Number of pages	5
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.00443-5
State	Published - 2009
Externally published	Yes

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abstract = "While providing digestion of food and absorption of nutrients, the gastrointestinal (GI) tract also possesses endocrine activity. Originally several GI peptides contributing to termination of food intake were identified. However, the GI tract also secretes orexigenic peptides. Among those are ?-casomorphin, motilin, and ghrelin. Ghrelin represents the most potent peripherally secreted orexigen and has pleiotropic effects on several tissues turning it into an important regulator of energy balance and glucose homeostasis. The orexigenic effects of these three peptides are mediated by different pathways through the central nervous system. This article summarizes through which mechanisms ?-casomorphin, motilin, and ghrelin stimulate food intake and which central pathways are involved.",

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AU - Nogueiras, R.

AU - Wiedmer, P.

AU - Perez-Tilve, D.

AU - Caton, S. J.

AU - Tschöp, M. H.

PY - 2009

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AB - While providing digestion of food and absorption of nutrients, the gastrointestinal (GI) tract also possesses endocrine activity. Originally several GI peptides contributing to termination of food intake were identified. However, the GI tract also secretes orexigenic peptides. Among those are ?-casomorphin, motilin, and ghrelin. Ghrelin represents the most potent peripherally secreted orexigen and has pleiotropic effects on several tissues turning it into an important regulator of energy balance and glucose homeostasis. The orexigenic effects of these three peptides are mediated by different pathways through the central nervous system. This article summarizes through which mechanisms ?-casomorphin, motilin, and ghrelin stimulate food intake and which central pathways are involved.

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SN - 9780080450469

SP - 577

EP - 581

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Gastrointestinal Signals: Stimulation

Abstract

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