TY - JOUR
T1 - Gastrointestinal secretory, motor, circulatory, and metabolic effects of prosomatostatin
AU - Konturek, S. J.
AU - Tasler, J.
AU - Jaworek, J.
AU - Pawlik, W.
AU - Walus, K. M.
AU - Schusdziarra, V.
AU - Meyers, C. A.
AU - Coy, D. H.
AU - Schally, A. V.
PY - 1981
Y1 - 1981
N2 - This study compares the gastrointestinal effects of somatostatin (SS) and its putative prohormone, prosomatostatin (Pro-SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-SS suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro-SS, at the doses tested, had no influence on mesenteric circulation oxygen uptake, and intestinal motility. We conclude that Pro-SS mimicks most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.
AB - This study compares the gastrointestinal effects of somatostatin (SS) and its putative prohormone, prosomatostatin (Pro-SS), a 28-amino acid peptide isolated from the hypothalamus and the gut, in conscious dogs with chronic gastric and pancreatic fistulae. Pro-SS suppressed the release of serum gastrin, insulin, and pancreatic polypeptide that occurs in response to feeding a meat meal in a manner similar to that seen with SS. However, in contrast to SS, which strongly reduced intestinal blood flow and oxygen consumption and stimulated intestinal motility, Pro-SS, at the doses tested, had no influence on mesenteric circulation oxygen uptake, and intestinal motility. We conclude that Pro-SS mimicks most of the gastrointestinal secretory actions of SS, but does not exhibit the intestinal circulatory, metabolic, and motor effects of SS.
UR - https://www.scopus.com/pages/publications/0019421061
U2 - 10.1073/pnas.78.3.1967
DO - 10.1073/pnas.78.3.1967
M3 - Article
C2 - 6112753
AN - SCOPUS:0019421061
SN - 0027-8424
VL - 78
SP - 1967
EP - 1971
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 3 I
ER -