Gastroenteropankreatische neuroendokrine neoplasien

Translated title of the contribution: Neuroendocrine neoplasms of the gastrointestinal tract

Matthias Schott, Günter Klöppel, Andreas Raffel, Andreas Saleh, Wolfram Trudo Knoefel, Werner A. Scherbaum

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Background: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are complex tumors whose incidence is rising and whose treatment requires precise classification and risk stratification. Method: Selective review of the relevant literature, including recently published guidelines. Results: GEP-NENs are initially classified by their degree of histological differentiation and their graded cell proliferation (Ki-67 index). In addition, there are GEP-NEN specific TNM staging protocols. The laboratory assessment includes the measurement of general tumor markers (synaptophysin, chromogranin A) as well as specific ones (hormones). The most important imaging technique for diagnosis is octreotide scintigraphy. The surgical treatment of GEP-NET is based on oncological resection criteria whose aim is to achieve locally radical resection while preserving as much organ function as possible. Metastases, too, may be amenable to resection. The treatment options for unresectable metastases include radiofrequency ablation and chemoembolization, both of which are palliative methods of reducing tumor volume and hormone production. Other chemotherapeutic and nuclear-medical treatments can be applied depending on the extent of metastatic spread, the proliferation index, and the degree of hormone production by the tumor. Conclusion: The accurate diagnosis and appropriate treatment of GEPNET currently gives most patients with this tumor a good prognosis, as long as it is discovered early. Early GEP-NETs have a favorable prognosis. Further advances in the diagnosis and treatment of this disease may result from structural changes in patient care, including the establishment of NET centers.

Translated title of the contributionNeuroendocrine neoplasms of the gastrointestinal tract
Original languageGerman
Pages (from-to)305-312
Number of pages8
JournalDeutsches Arzteblatt
Issue number18
StatePublished - 6 May 2011


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