Gastrinoma - Morphological aspects

Günter Klöppel, Martin Anlauf

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Gastrinomas are defined as gastrin producing tumors that are associated with an elevated fasting gastrin serum level, a positive gastrin secretin stimulation test and certain clinical symptoms, e.g. recurrent peptic ulcer disease and occasionally diarrhea, the socalled Zollinger-Ellison syndrome. Most gastrinomas occur in the duodenum (approx. 70%) and not in the pancreas. The duodenal gastrinomas are small, and when they occur in association with the genetic syndrome of multiple endocrine neoplasia type 1 (MEN1), they are multicentric and originate from precursor lesions. The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalWiener Klinische Wochenschrift
Volume119
Issue number19-20
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Duodenum
  • Gastrinoma
  • MEN1
  • Pancreas

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