GALLENSAUREN UND CHOLOSTASE

Translated title of the contribution: Bile acids and cholestasis

H. Popper, H. Greim, P. Czygan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Cholestasis may be brought about by alterations of the bile acid metabolism in the human liver. It is certain, however, that bile acid congestion is responsible for the sequelae of cholestasis, in that the microsomal biotransformation system is altered by the detergent action of bile acid. In cholestasis, and probably in cholate stasis as well, this may at first be delayed by alterations in the bile acid metabolism (alternate pathways). But subsequently, at any rate in mechanical cholestasis, the process leads to destruction of the liver as the consequence of increased production and accumulation of dehydroxylated bile acid with a detergent action. In the rat this increase of dehydroxylated bile acid is prevented by the activation of hydroxylation reactions that are more or less dormant in the normal condition.

Translated title of the contributionBile acids and cholestasis
Original languageGerman
Pages (from-to)451-456
Number of pages6
JournalZeitschrift fur Gastroenterologie
Volume11
Issue number5
StatePublished - 1973
Externally publishedYes

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