Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Guoxin Wu; Paul Zuck; Shih Lin Goh; Jeffrey M. Milush; Poonam Vohra; Joseph K. Wong; Ma Somsouk; Steven A. Yukl; Barbara L. Shacklett; Nicolas Chomont; Ashley T. Haase; Hiroyu Hatano; Timothy W. Schacker; Steven G. Deeks; Daria J. Hazuda; Peter W. Hunt; Bonnie J. Howell

doi:10.1093/infdis/jiab121

Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Guoxin Wu
, Paul Zuck
, Shih Lin Goh
, Jeffrey M. Milush
, Poonam Vohra
, Joseph K. Wong
, Ma Somsouk
, Steven A. Yukl
, Barbara L. Shacklett
, Nicolas Chomont
, Ashley T. Haase
, Hiroyu Hatano
, Timothy W. Schacker
, Steven G. Deeks
, Daria J. Hazuda
, Peter W. Hunt
, Bonnie J. Howell

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

Original language	English
Pages (from-to)	1593-1598
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	224
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiab121
State	Published - 1 Nov 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIV
HIV persistence
biomarker
fine needle aspirates
gag p24
lymph nodes
rectal biopsy

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10.1093/infdis/jiab121

Cite this

Wu, G., Zuck, P., Goh, S. L., Milush, J. M., Vohra, P., Wong, J. K., Somsouk, M., Yukl, S. A., Shacklett, B. L., Chomont, N., Haase, A. T., Hatano, H., Schacker, T. W., Deeks, S. G., Hazuda, D. J., Hunt, P. W., & Howell, B. J. (2021). Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response. Journal of Infectious Diseases, 224(9), 1593-1598. https://doi.org/10.1093/infdis/jiab121

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title = "Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response",

abstract = "We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.",

keywords = "HIV, HIV persistence, biomarker, fine needle aspirates, gag p24, lymph nodes, rectal biopsy",

author = "Guoxin Wu and Paul Zuck and Goh, \{Shih Lin\} and Milush, \{Jeffrey M.\} and Poonam Vohra and Wong, \{Joseph K.\} and Ma Somsouk and Yukl, \{Steven A.\} and Shacklett, \{Barbara L.\} and Nicolas Chomont and Haase, \{Ashley T.\} and Hiroyu Hatano and Schacker, \{Timothy W.\} and Deeks, \{Steven G.\} and Hazuda, \{Daria J.\} and Hunt, \{Peter W.\} and Howell, \{Bonnie J.\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].",

year = "2021",

month = nov,

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doi = "10.1093/infdis/jiab121",

language = "English",

volume = "224",

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Wu, G, Zuck, P, Goh, SL, Milush, JM, Vohra, P, Wong, JK, Somsouk, M, Yukl, SA, Shacklett, BL, Chomont, N, Haase, AT, Hatano, H, Schacker, TW, Deeks, SG, Hazuda, DJ, Hunt, PW & Howell, BJ 2021, 'Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response', Journal of Infectious Diseases, vol. 224, no. 9, pp. 1593-1598. https://doi.org/10.1093/infdis/jiab121

TY - JOUR

T1 - Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

AU - Wu, Guoxin

AU - Zuck, Paul

AU - Goh, Shih Lin

AU - Milush, Jeffrey M.

AU - Vohra, Poonam

AU - Wong, Joseph K.

AU - Somsouk, Ma

AU - Yukl, Steven A.

AU - Shacklett, Barbara L.

AU - Chomont, Nicolas

AU - Haase, Ashley T.

AU - Hatano, Hiroyu

AU - Schacker, Timothy W.

AU - Deeks, Steven G.

AU - Hazuda, Daria J.

AU - Hunt, Peter W.

AU - Howell, Bonnie J.

N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

PY - 2021/11/1

Y1 - 2021/11/1

N2 - We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

AB - We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

KW - HIV

KW - HIV persistence

KW - biomarker

KW - fine needle aspirates

KW - gag p24

KW - lymph nodes

KW - rectal biopsy

UR - https://www.scopus.com/pages/publications/85121324773

U2 - 10.1093/infdis/jiab121

DO - 10.1093/infdis/jiab121

M3 - Article

C2 - 33693750

AN - SCOPUS:85121324773

SN - 0022-1899

VL - 224

SP - 1593

EP - 1598

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -

Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Abstract

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Keywords

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