Abstract
The distribution of functional neurotransmitter receptors on the surface of neurons is highly relevant for synaptic transmission and signal processing. To map functional GABAA and GABAB receptors on the somadendritic membrane of rat neocortical layer V pyramidal neurons we used patch-clamp recording in combination with infrared-guided laser stimulation to release γ-aminobutyric acid (GABA) photolytically. The data strongly suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma. Such a specific distribution of GABAA and GABAB receptors may serve to compensate for differences in electrotonic voltage attenuation between GABAA and GABAB receptor-mediated inhibitory postsynaptic potentials (IPSPs).
Original language | English |
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Pages (from-to) | 1065-1069 |
Number of pages | 5 |
Journal | European Journal of Neuroscience |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Caged compounds
- Dendrite
- GABA
- Photostimulation
- Rat