GABAA and GABAB receptors on neocortical neurons are differentially distributed

M. Eder, G. Rammes, W. Zieglgänsberger, H. U. Dodt

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The distribution of functional neurotransmitter receptors on the surface of neurons is highly relevant for synaptic transmission and signal processing. To map functional GABAA and GABAB receptors on the somadendritic membrane of rat neocortical layer V pyramidal neurons we used patch-clamp recording in combination with infrared-guided laser stimulation to release γ-aminobutyric acid (GABA) photolytically. The data strongly suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma. Such a specific distribution of GABAA and GABAB receptors may serve to compensate for differences in electrotonic voltage attenuation between GABAA and GABAB receptor-mediated inhibitory postsynaptic potentials (IPSPs).

Original languageEnglish
Pages (from-to)1065-1069
Number of pages5
JournalEuropean Journal of Neuroscience
Volume13
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Caged compounds
  • Dendrite
  • GABA
  • Photostimulation
  • Rat

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