GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices

U. Heinemann; B. Hamon; A. Konnerth

doi:10.1016/0304-3940(84)90529-9

GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices

U. Heinemann, B. Hamon, A. Konnerth

Max Planck Institute of Psychiatry

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Reductions in extracellular free Ca²⁺-concentration ([Ca²⁺]_o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. They reflect Ca²⁺-movements along its electrochemical gradient into pre- and postsynaptic elements. Amino acidinduced reductions in [Ca²⁺]_o are predominantly caused by postsynaptic Ca²⁺ entry. Under conditions of blocked chemical synaptic transmission, a presynaptic component of extracellular Ca²⁺ loss becomes apparent during stimulation of the Schaffer collateral/commissural fibers system in stratum radiatum/moleculare. GABA, both iontophoretically and bath applied, always reduces pre- and postsynaptic components of [Ca²⁺]_o changes. Baclofen regularly affects postsynaptic Ca²⁺ entry and has frequently also a suppressant action on presynaptic Ca²⁺ entry in are CA1.

Original language	English
Pages (from-to)	295-300
Number of pages	6
Journal	Neuroscience Letters
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(84)90529-9
State	Published - 29 Jun 1984
Externally published	Yes

Keywords

area CA1
calcium
hippocampus
rat
slice
γ-aminobutyric acid

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10.1016/0304-3940(84)90529-9

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title = "GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices",

abstract = "Reductions in extracellular free Ca2+-concentration ([Ca2+]o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. They reflect Ca2+-movements along its electrochemical gradient into pre- and postsynaptic elements. Amino acidinduced reductions in [Ca2+]o are predominantly caused by postsynaptic Ca2+ entry. Under conditions of blocked chemical synaptic transmission, a presynaptic component of extracellular Ca2+ loss becomes apparent during stimulation of the Schaffer collateral/commissural fibers system in stratum radiatum/moleculare. GABA, both iontophoretically and bath applied, always reduces pre- and postsynaptic components of [Ca2+]o changes. Baclofen regularly affects postsynaptic Ca2+ entry and has frequently also a suppressant action on presynaptic Ca2+ entry in are CA1.",

keywords = "area CA1, calcium, hippocampus, rat, slice, γ-aminobutyric acid",

author = "U. Heinemann and B. Hamon and A. Konnerth",

note = "Funding Information: This research was supported by DFG Grants He 1128/2-2, 2-3 and He 1128/3 as well as by the SFB 220. The technical assistance of G. Schuster in the present experiments is gratefully acknowledged.",

year = "1984",

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doi = "10.1016/0304-3940(84)90529-9",

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pages = "295--300",

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T1 - GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices

AU - Heinemann, U.

AU - Hamon, B.

AU - Konnerth, A.

N1 - Funding Information: This research was supported by DFG Grants He 1128/2-2, 2-3 and He 1128/3 as well as by the SFB 220. The technical assistance of G. Schuster in the present experiments is gratefully acknowledged.

PY - 1984/6/29

Y1 - 1984/6/29

N2 - Reductions in extracellular free Ca2+-concentration ([Ca2+]o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. They reflect Ca2+-movements along its electrochemical gradient into pre- and postsynaptic elements. Amino acidinduced reductions in [Ca2+]o are predominantly caused by postsynaptic Ca2+ entry. Under conditions of blocked chemical synaptic transmission, a presynaptic component of extracellular Ca2+ loss becomes apparent during stimulation of the Schaffer collateral/commissural fibers system in stratum radiatum/moleculare. GABA, both iontophoretically and bath applied, always reduces pre- and postsynaptic components of [Ca2+]o changes. Baclofen regularly affects postsynaptic Ca2+ entry and has frequently also a suppressant action on presynaptic Ca2+ entry in are CA1.

AB - Reductions in extracellular free Ca2+-concentration ([Ca2+]o) result from neuronal activation and can be induced by repetitive electrical stimulation or by application of excitatory amino acids. They reflect Ca2+-movements along its electrochemical gradient into pre- and postsynaptic elements. Amino acidinduced reductions in [Ca2+]o are predominantly caused by postsynaptic Ca2+ entry. Under conditions of blocked chemical synaptic transmission, a presynaptic component of extracellular Ca2+ loss becomes apparent during stimulation of the Schaffer collateral/commissural fibers system in stratum radiatum/moleculare. GABA, both iontophoretically and bath applied, always reduces pre- and postsynaptic components of [Ca2+]o changes. Baclofen regularly affects postsynaptic Ca2+ entry and has frequently also a suppressant action on presynaptic Ca2+ entry in are CA1.

KW - area CA1

KW - calcium

KW - hippocampus

KW - rat

KW - slice

KW - γ-aminobutyric acid

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DO - 10.1016/0304-3940(84)90529-9

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SN - 0304-3940

VL - 47

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EP - 300

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices

Abstract

Keywords

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