G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

Ondřej Viklický; Jaroslav A. Hubáček; Štefan Vítko; Uwe W. Heemann; Barna Vasarhelyi; Mathias Kohnle; Vladimír Teplan; Jiří Lácha; Attila J. Szabó

doi:10.1159/000066346

G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

Ondřej Viklický, Jaroslav A. Hubáček, Štefan Vítko, Uwe W. Heemann, Barna Vasarhelyi, Mathias Kohnle, Vladimír Teplan, Jiří Lácha, Attila J. Szabó

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8 Scopus citations

Abstract

Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β₃ subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

Original language	English
Pages (from-to)	245-249
Number of pages	5
Journal	Kidney and Blood Pressure Research
Volume	25
Issue number	4
DOIs	https://doi.org/10.1159/000066346
State	Published - 2002
Externally published	Yes

Keywords

Endothelial nitric oxide synthase
G protein
Gene polymorphism
Kidney transplantation
Long-term graft survival

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10.1159/000066346

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@article{0e530424b3834701b85199bbbf09ec2d,

title = "G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function",

abstract = "Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.",

keywords = "Endothelial nitric oxide synthase, G protein, Gene polymorphism, Kidney transplantation, Long-term graft survival",

author = "Ond{\v r}ej Viklick{\'y} and Hub{\'a}{\v c}ek, {Jaroslav A.} and {\v S}tefan V{\'i}tko and Heemann, {Uwe W.} and Barna Vasarhelyi and Mathias Kohnle and Vladim{\'i}r Teplan and Ji{\v r}{\'i} L{\'a}cha and Szab{\'o}, {Attila J.}",

year = "2002",

doi = "10.1159/000066346",

language = "English",

volume = "25",

pages = "245--249",

journal = "Kidney and Blood Pressure Research",

issn = "1420-4096",

publisher = "S. Karger AG",

number = "4",

}

TY - JOUR

T1 - G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

AU - Viklický, Ondřej

AU - Hubáček, Jaroslav A.

AU - Vítko, Štefan

AU - Heemann, Uwe W.

AU - Vasarhelyi, Barna

AU - Kohnle, Mathias

AU - Teplan, Vladimír

AU - Lácha, Jiří

AU - Szabó, Attila J.

PY - 2002

Y1 - 2002

N2 - Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

AB - Background: Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β3 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. Methods: Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. Results: There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. Conclusions: Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.

KW - Endothelial nitric oxide synthase

KW - G protein

KW - Gene polymorphism

KW - Kidney transplantation

KW - Long-term graft survival

UR - http://www.scopus.com/inward/record.url?scp=19044383568&partnerID=8YFLogxK

U2 - 10.1159/000066346

DO - 10.1159/000066346

M3 - Article

C2 - 12424427

AN - SCOPUS:19044383568

SN - 1420-4096

VL - 25

SP - 245

EP - 249

JO - Kidney and Blood Pressure Research

JF - Kidney and Blood Pressure Research

IS - 4

ER -

G-protein beta-3-subunit and eNOS gene polymorphism in transplant recipients with long-term renal graft function

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Keywords

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