Future aspects of bioprocess monitoring

Thomas Becker, Bernd Hitzmann, K. Muffler, Ralf Pörtner, Kenneth F. Reardon, Frank Stahl, Roland Ulber

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

77 Scopus citations

Abstract

Nature has the impressive ability to efficiently and precisely control biological processes by applying highly evolved principles and using minimal space and relatively simple building blocks. The challenge is to transfer these principles into technically applicable and precise analytical systems that can be used for many applications. This article summarizes some of the new approaches in sensor technology and control strategies for different bioprocesses such as fermentations, biotransformations, and downstream processes. It focuses on bio- and chemosensors, optical sensors, DNA and protein chip technology, software sensors, and modern aspects of data evaluation for improved process monitoring and control.

Original languageEnglish
Title of host publicationWhite Biotechnology
EditorsRoland Ulber, Dieter Sell, T.W. Babel, S.-O. Enfors, M. Hoare, I. Endo, A. Fiechter, W.-S. Hu, Bo Mattiasson, H. Sahm, C. Wandrey, G. Stephanopoulos, G.T. Tsao, J.-J. Zhong, J. Nielsen, K. Schuegerl, U. Stockar
Pages249-293
Number of pages45
DOIs
StatePublished - 4 Nov 2006
Externally publishedYes

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume105
ISSN (Print)0724-6145

Keywords

  • Biosensors
  • Microarray technologies
  • Process control
  • Process monitoring
  • Software sensors

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