Functional ribosome biogenesis is a prerequisite for p53 destabilization: Impact of chemotherapy on nucleolar functions and RNA metabolism

Kaspar Burger, Dirk Eick

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as a highly sensitive sensor of cellular stress and an important regulator of the tumor suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signaling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilize p53 by inhibiting nucleolar functions.

Original languageEnglish
Pages (from-to)1133-1143
Number of pages11
JournalBiological Chemistry
Volume394
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Chemotherapy
  • Kinase inhibitor
  • Ribosome biogenesis
  • TRNA processing
  • Tumor suppressor p53

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