Functional redundancy of NSCL-1 and NeuroD during development of the petrosal and vestibulocochlear ganglia

Marcus Krüger, Thomas Schmid, Sonja Krüger, Eva Bober, Thomas Braun

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

To study the role of different members of the bHLH gene family for sensory organ development we have generated NSCL-1 and NeuroD compound-mutant mice. Double homozygous animals were characterized by a more severe reduction of the petrosal and vestibulocochlear ganglia than NeuroD-knockout mice. The more severe reduction of the petrosal and vestibulocochlear ganglia in double-knockout mice indicates overlapping functions of the two genes during neuronal development. Interestingly, we also found that the two genes are jointly regulated by thyroid hormone during sensory hair cell development. We further present a detailed expression analysis of NSCL-1 and NSCL-2 during sensory neuron development. NSCL-1 expression was detected in all developing cranial ganglia including the petrosal and vestibulocochlear ganglion, in inner and outer hair cells of the organ of Corti and in hair cells of the vestibular system. Expression domains in other sensory structures include the retina, Merkel cells of the developing skin and sensory cells of the tongue. The expression of NSCL-2 was restricted to developing cranial ganglia, the retina and the vestibular nerve. Both NSCL-1 and NSCL-2 genes are active only in postmitotic neurons, indicating a role for neuronal cell migration and/or differentiation within the sensory system.

Original languageEnglish
Pages (from-to)1581-1590
Number of pages10
JournalEuropean Journal of Neuroscience
Volume24
Issue number6
DOIs
StatePublished - Sep 2006
Externally publishedYes

Keywords

  • Cranial ganglia
  • Inner ear
  • Mouse
  • Thyroid hormone

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