Functional organization of a eukaryotic proteome by systematic analysis of protein complexes

Anne Claude Gavin; Roland Krause; Markus Bösche; Paola Grandi; Andreas Bauer; Jörg Schulz; Jens Rick; Peer Bork; Bertrand Seraphin; Gitte Neubauer; Giulio Superti-Furga; Bernhard Kuster

Functional organization of a eukaryotic proteome by systematic analysis of protein complexes

Anne Claude Gavin
, Roland Krause
, Markus Bösche
, Paola Grandi
, Andreas Bauer
, Jörg Schulz
, Jens Rick
, Peer Bork
, Bertrand Seraphin
, Gitte Neubauer
, Giulio Superti-Furga
, Bernhard Kuster

Cellzome GmbH
European Molecular Biology Laboratory Heidelberg
Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique - Aix-Marseille University

Research output: Contribution to conference › Paper › peer-review

Abstract

A comprehensive map of the network of protein complexes in baker's yeast, a model system relevant to human biology was presented. An outline of a eukaryotic proteome as a network of protein complexes was provided at a level of organization beyond binary interactions. It was found that the majority of proteins participated in protein complexes. It was demonstrated that the sharing of components between protein complexes of different overall function is very common and contribute to explain how biological complexity is generated from limited sets of genes.

Original language	English
Pages	127-128
Number of pages	2
State	Published - 2002
Externally published	Yes
Event	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: 2 Jun 2002 → 6 Jun 2002

Conference

Conference	Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
Country/Territory	United States
City	Orlando, FL
Period	2/06/02 → 6/06/02

Cite this

Gavin, A. C., Krause, R., Bösche, M., Grandi, P., Bauer, A., Schulz, J., Rick, J., Bork, P., Seraphin, B., Neubauer, G., Superti-Furga, G., & Kuster, B. (2002). Functional organization of a eukaryotic proteome by systematic analysis of protein complexes. 127-128. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

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title = "Functional organization of a eukaryotic proteome by systematic analysis of protein complexes",

abstract = "A comprehensive map of the network of protein complexes in baker's yeast, a model system relevant to human biology was presented. An outline of a eukaryotic proteome as a network of protein complexes was provided at a level of organization beyond binary interactions. It was found that the majority of proteins participated in protein complexes. It was demonstrated that the sharing of components between protein complexes of different overall function is very common and contribute to explain how biological complexity is generated from limited sets of genes.",

author = "Gavin, \{Anne Claude\} and Roland Krause and Markus B{\"o}sche and Paola Grandi and Andreas Bauer and J{\"o}rg Schulz and Jens Rick and Peer Bork and Bertrand Seraphin and Gitte Neubauer and Giulio Superti-Furga and Bernhard Kuster",

year = "2002",

language = "English",

pages = "127--128",

note = "Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics ; Conference date: 02-06-2002 Through 06-06-2002",

}

Gavin, AC, Krause, R, Bösche, M, Grandi, P, Bauer, A, Schulz, J, Rick, J, Bork, P, Seraphin, B, Neubauer, G, Superti-Furga, G & Kuster, B 2002, 'Functional organization of a eukaryotic proteome by systematic analysis of protein complexes', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 2/06/02 - 6/06/02 pp. 127-128.

TY - CONF

T1 - Functional organization of a eukaryotic proteome by systematic analysis of protein complexes

AU - Gavin, Anne Claude

AU - Krause, Roland

AU - Bösche, Markus

AU - Grandi, Paola

AU - Bauer, Andreas

AU - Schulz, Jörg

AU - Rick, Jens

AU - Bork, Peer

AU - Seraphin, Bertrand

AU - Neubauer, Gitte

AU - Superti-Furga, Giulio

AU - Kuster, Bernhard

PY - 2002

Y1 - 2002

N2 - A comprehensive map of the network of protein complexes in baker's yeast, a model system relevant to human biology was presented. An outline of a eukaryotic proteome as a network of protein complexes was provided at a level of organization beyond binary interactions. It was found that the majority of proteins participated in protein complexes. It was demonstrated that the sharing of components between protein complexes of different overall function is very common and contribute to explain how biological complexity is generated from limited sets of genes.

AB - A comprehensive map of the network of protein complexes in baker's yeast, a model system relevant to human biology was presented. An outline of a eukaryotic proteome as a network of protein complexes was provided at a level of organization beyond binary interactions. It was found that the majority of proteins participated in protein complexes. It was demonstrated that the sharing of components between protein complexes of different overall function is very common and contribute to explain how biological complexity is generated from limited sets of genes.

UR - https://www.scopus.com/pages/publications/2442667973

M3 - Paper

AN - SCOPUS:2442667973

SP - 127

EP - 128

T2 - Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics

Y2 - 2 June 2002 through 6 June 2002

ER -

Functional organization of a eukaryotic proteome by systematic analysis of protein complexes

Abstract

Conference

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