Functional effects of 13 Rare PRSS1 variants presumed to cause chronic pancreatitis

Keyphrases

• Functional Impact 100%
• Chronic Pancreatitis 100%
• PRSS1 100%
• Autoactivation 83%
• Chymotrypsin C 66%
• Endoplasmic Reticulum Stress (ER stress) 33%
• Misfolding 33%
• Trypsinogen 33%
• Clinical Significance 16%
• Functional Phenotype 16%
• Disease-causing mutations 16%
• Functional Change 16%
• Trypsinogen Activation 16%
• Functional Comparison 16%
• Phenotypic Change 16%
• Cell Secretion 16%
• Cysteine Modification 16%
• Intracellular Retention 16%
• Cationic Trypsinogen 16%
• Hereditary Pancreatitis 16%
• Impaired Secretion 16%

Biochemistry, Genetics and Molecular Biology

• Secretion (Process) 100%
• Chymotrypsin C 80%
• Trypsinogen 80%
• Endoplasmic Reticulum Stress 40%
• Wild Type 20%
• Cellular Secretion 20%
• Induced Mutation 20%
• Cysteine 20%